dc.contributor.author | Can, Özgür Devrim | |
dc.contributor.author | Özkay, Ümide Demir | |
dc.contributor.author | Öztürk, Nilgün | |
dc.contributor.author | Öztürk, Yusuf | |
dc.date.accessioned | 2019-10-19T14:16:27Z | |
dc.date.available | 2019-10-19T14:16:27Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1388-0209 | |
dc.identifier.uri | https://dx.doi.org/10.3109/13880200903305500 | |
dc.identifier.uri | https://hdl.handle.net/11421/13161 | |
dc.description | WOS: 000281304800012 | en_US |
dc.description | PubMed ID: 20673180 | en_US |
dc.description.abstract | Context: Investigating potential central nervous system (CNS) activities of Crataegus monogyna Jacq. (Rosaceae), hawthorn, fruit extracts. Objective: Evaluating CNS effects and analgesic activities of hawthorn fruit extracts based on the traditional uses of the plant for neurosedative and pain killer actions. Materials and methods: Effects of hawthorn pulp (HPE) and seed extracts (HSE) at the dose range of 1-1000 mg/kg were examined on anxiety level, spontaneous locomotor activity, motor coordination, and nociceptive perception of mice. Morphine was used as a reference drug. Results: HPE (100-1000 mg/kg) and HSE (10-1000 mg/kg) significantly decreased not only the exploratory behaviors in hole-board experiments, but also the spontaneous locomotor activities in activity cage tests. The same doses of extracts were found to be ineffective in Rota-Rod tests of mice. In tail-clip, hot-plate, and acetic acid-induced writhing tests, quite potent and dose-dependent analgesic activities were seen at 100-1000 mg/kg doses of HPE and 10-1000 mg/kg doses of HSE. Analgesic effects observed in all analgesia tests were antagonized by naloxone. Discussion: Significant and dose-dependent decreases in spontaneous locomotor activities and exploratory behaviors of animals suggested CNS depressant activities of both extracts. Complete naloxone antagonism in all applied analgesia tests indicated opioid-related analgesic activities of both extracts. Conclusion: These findings seem to support the traditional use of this plant to treat stress, nervousness, sleep disorders, and pain control. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Informa Healthcare | en_US |
dc.relation.isversionof | 10.3109/13880200903305500 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Analgesia | en_US |
dc.subject | Crataegus | en_US |
dc.subject | Exploratory Behavior | en_US |
dc.subject | Hawthorn | en_US |
dc.subject | Locomotor Activity | en_US |
dc.subject | Motor Coordination | en_US |
dc.subject | Opioid | en_US |
dc.title | Effects of hawthorn seed and pulp extracts on the central nervous system | en_US |
dc.type | article | en_US |
dc.relation.journal | Pharmaceutical Biology | en_US |
dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 924 | en_US |
dc.identifier.endpage | 931 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.institutionauthor | Can, Özgür Devrim | |
dc.contributor.institutionauthor | Özkay, Ümide Demir | |
dc.contributor.institutionauthor | Öztürk, Nilgün | |
dc.contributor.institutionauthor | Öztürk, Yusuf | |