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dc.contributor.authorCan, Nafiz Öncü
dc.contributor.authorArli, Göksel
dc.date.accessioned2019-10-19T14:02:54Z
dc.date.available2019-10-19T14:02:54Z
dc.date.issued2010
dc.identifier.issn1060-3271
dc.identifier.urihttps://hdl.handle.net/11421/12436
dc.descriptionPubMed: 20922937en_US
dc.description.abstractDevelopment and validation of an RP-HPLC method for determination of levetiracetam in pharmaceutical tablets is described. The separation and quantification of levetiracetam and caffeine (internal standard) were performed using a single analytical procedure with two different types of stationary phases, conventional Phenomenex Gemini C18 (100 × 4.6 mm, 5 µm) and Merck Chromolith Performance RP18e (100 × 4.6 mm, macropore size 2 mm, micropore size 13 nm) monolithic silica. Five-microliter aliquots of samples were injected into the system and eluted using water-acetonitrile (90 + 10, v/v) mobile phase pumped at the rate of 1 mL/min. The analyte peaks were detected at 200 nm using a diode array detector with adequate resolution. Validation studies were performed using the method recommended by the International Conference on Harmonization, the U.S. Pharmacopeia, and AOAC INTERNATIONAL, which includes accuracy, precision, range, limits, robustness, and system suitability parameters. Levetiracetam and caffeine were detected in about 7 min using the conventional column, whereas less than 5 min was required when the monolithic column was used. Calibration plots had r values close to unity in the range of 0.8-8.0 µg/mL. Assay of levetiracetam in a tablet formulation was demonstrated as an application to real samples.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleReversed-phase HPLC analysis of levetiracetam in tablets using monolithic and conventional c18 silica columnen_US
dc.typearticleen_US
dc.relation.journalJournal of AOAC Internationalen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalıen_US
dc.identifier.volume93en_US
dc.identifier.issue4en_US
dc.identifier.startpage1077en_US
dc.identifier.endpage1085en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorCan, Nafiz Öncü
dc.contributor.institutionauthorArli, Göksel


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