Yayıncı "Pergamon-Elsevier Science LTD" Makale Koleksiyonu için listeleme
Toplam kayıt 10, listelenen: 1-10
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Anti-nociceptive effect of vitexin mediated by the opioid system in mice
(Pergamon-Elsevier Science LTD, 2013)In the present study, we determined the potential anti-nociceptive activity of vitexin, a C-glycosylated flavone, by conducting some acute nociceptive tests in mice. Centrally mediated anti-nociceptive effect was evaluated ... -
Antidepressant-like effect of gallic acid in mice: Dual involvement of serotonergic and catecholaminergic systems
(Pergamon-Elsevier Science LTD, 2017)Aims: This study was planned to examine the antidepressant potency of gallic acid (30 and 60 mg/kg), a phenolic acid widely distributed in nature, together with its possible underlying monoaminergic mechanisms. Main methods: ... -
Antithrombotic effects of ethanol extract of Crataegus orientalis in the carrageenan-induced mice tail thrombosis model
(Pergamon-Elsevier Science LTD, 2011)Introduction: Crataegus species (common name is Hawthorn) are medicinal plants, which have flavonoids, triterpene acids, proanthocyanidins, and organic acids as main constituents, used in the treatment of cardiovascular ... -
Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines
(Pergamon-Elsevier Science LTD, 2016)In the current study, 14 new benzothiazole-piperazine compounds were designed to meet the structural requirements of acetylcholine esterase (AChE) inhibitors. The target compounds were synthesised in three steps. Structures ... -
The Effects of Glyburide and Insulin on the Cardiac-Performance in Rats With Non-Insulin-Dependent Diabetes-Mellitus
(Pergamon-Elsevier Science LTD, 1993)1. The effects Of glyburide were studied on the myocardial contractile force and heart rate in the atria isolated from non-diabetic and non-insulin-dependent diabetic rats (diabetic). 2. In order to examine the myocardial ... -
Effects of streptozotocin-induced diabetes and insulin on calcium responsiveness of the rat vas deferens
(Pergamon-Elsevier Science LTD, 2006)In the present study, effects of streptozotocin-induced diabetes and insulin treatment on the reactivity of rat vas deferens to KCl and calmidazolium, a calmodulin antagonist, were evaluated and calmodulin levels in vas ... -
An in vivo database model for pharmacological and physiological dosage for experimental animals
(Pergamon-Elsevier Science LTD, 2009)We developed a database compiling in vivo doses of compounds for various activities in certain animal species. The related database covers almost 100 years of experiments. The conceptual scheme of the database was created ... -
Increased Alpha(1)-Adrenergic Responsiveness of Alloxan-Diabetic Rat Atria - Effects of Insulin Therapy and Thyroidectomy
(Pergamon-Elsevier Science LTD, 1994)1. Experimental models of diabetes are increasingly used for the investigation of cardiovascular complications as well as other complications due to diabetes mellitus. However, animal models have been used in relatively ... -
Opioid system mediated anti-nociceptive effect of agomelatine in mice
(Pergamon-Elsevier Science LTD, 2016)Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these ... -
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy
(Pergamon-Elsevier Science LTD, 2014)Aims: The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role ...