Güncel Gönderiler: Farmakoloji Anabilim Dalı
Toplam kayıt 177, listelenen: 161-177
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The imidazoline receptors and ligands in pain modulations
(Wolters Kluwer Medknow Publications, 2015)Pain is an unpleasant experience and effects daily routine negatively. Although there are various drugs, many of them are not entirely successful in relieving pain, since pain modulation is a complex process involving ... -
Effects of phenolic acids on gastrointestinal smooth muscle complications in streptozotocine-induced diabetic rats
(Tubitak Scientific & Technical Research Council Turkey, 2012)Aim: To identify the effects of antioxidants on gastrointestinal smooth muscle complications in 6-week streptozotocine (STZ)-induced diabetic rats. Materials and methods: The following steps were carried out: I. Three weeks ... -
Effect of phenolic acids on functions of rat aorta, vas deferens and on metabolic changes in streptozotocin-induced diabetes
(Medknow Publications & Media Pvt LTD, 2012)Objectives: This study aimed to investigate the effects of antioxidant treatment on streptozotocin (STZ)-induced diabetic metabolic and smooth muscle (SM) complications in rats. Materials and Methods: Threeweeks after STZ ... -
Antihyperalgesic Activity of Atomoxetine on Diabetes-Induced Neuropathic Pain: Contribution of Noradrenergic and Dopaminergic Systems
(MDPI, 2018)Atomoxetine is a selective noradrenaline reuptake inhibitor drug. Based on the knowledge that agents increasing monoamine levels in the central nervous system have therapeutic potential for neuropathic pain, it is planned ... -
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy
(Pergamon-Elsevier Science LTD, 2014)Aims: The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role ... -
The Opiodergic, Serotonergic and Noradrenergic Modulation of Ferulic Acid-Induced Central Analgesia
(Oxford University Press, 2016)… -
Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms
(Wiley, 2016)In this study, we investigated the effects of subacute agomelatine (40 and 80 mg/kg) administration on chronic hyperglycemia, metabolic parameters, and pain perception in streptozotocin-induced diabetic rats. Fasting blood ... -
Evaluation of the Antidiabetic Property of Capparis Ovata Desf. Var. Palaestina Zoh. Extracts Using In vivo and In vitro Approaches
(Bentham Science Publ LTD, 2018)Background and Objective: This paper is focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. Methods: Alloxan-induced ... -
Potassium and TRP Channels Are Involved in Analgesic Effects of NSAIDs in Tail Immersion Test
(Oxford University Press, 2016)… -
The Role of TRP and K+ Ion Channels in Analgesic Effect of NSAIDs
(Marmara University, Inst Health Sciences, 2018)Objective: We aimed to clarify the possible contributions of TRP and voltage-dependent K+ channels to the analgesic effects of diclofenac, ketoprofen, etodolac, and dipyrone using the nonselective TRP channel blocker ... -
Antinociceptive effect of methanol extract of Capparis ovata in mice
(Taylor & Francis LTD, 2010)Context: Capparis ovata Desf. (Capparaceae) grows widely in Turkey. Flower buds and fruits of the plant are used in folk medicine for their analgesic, antirheumatismal, and diuretic effects. Objective:This study evaluated ... -
Antithrombotic effects of ethanol extract of Crataegus orientalis in the carrageenan-induced mice tail thrombosis model
(Pergamon-Elsevier Science LTD, 2011)Introduction: Crataegus species (common name is Hawthorn) are medicinal plants, which have flavonoids, triterpene acids, proanthocyanidins, and organic acids as main constituents, used in the treatment of cardiovascular ... -
The possible mechanisms of protocatechuic acid-induced central analgesia
(Elsevier Science BV, 2018)It is aimed to investigate the central antinociceptive effect of protocatechuic acid and the involvement of stimulation of opioidergic, serotonin 5-HT2A/2C. alpha 2-adrenergic and muscarinic receptors in protocatechuic ... -
Evaluation of the antithrombotic effects of Crataegus monogyna and Crataegus davisii in the carrageenan-induced tail thrombosis model
(Informa Healthcare, 2015)Context: Crataegus species are widely used as herbal medicines for preventing cardiovascular diseases (CVDs). However, there are no studies on the effects of Crataegus monogyna Jacq. (Rosaceae) and C. davisii Browicz on ... -
Potential Antithrombotic Effect of Crataegus Species
(Assoc Pharmaceutical Teachers India, 2018)Hawthorn (Crataegus), a highly important medicinal and aromatic plant, has been used for many years in the treatment of various diseases. In folk medicine, hawthorn has been used to treat asthma, hyperlipidemia, heart ...
