Güncel Gönderiler: Biyokimya Anabilim Dalı
Toplam kayıt 103, listelenen: 61-80
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Fe3O4 Nanopowders: Genomic and Apoptotic Evaluations on A549 Lung Adenocarcinoma Cell Line
(Routledge Journals, Taylor & Francis LTD, 2019)The magnetite nanoparticles are progressively used in a wide range of biological applications. In the present study, we purposed to show apoptosis-inducing ability of Fe3O4 nanopowders on A549 cells. In addition, the toxic ... -
A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells
(Turkish Pharmacists Assoc, 2019)Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt. Materials ... -
The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics
(Tubitak Scientific & Technical Research Council Turkey, 2015)Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ... -
Induction of apoptosis in lung adenocarcinoma and glioma cells by some oxadiazole derivatives
(Springer Birkhauser, 2014)Oxadiazoles have received much attention due to their wide range of biological activities including antitumor activity. In this study, we aimed to study apoptotic effects of some 1,3,4-oxadiazole derivatives on human lung ... -
Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines
(Springer, 2015)Aesculus hippocastanum (the horse chestnut) seed extract has a wide variety of biochemical and pharmacological effects including anti-inflammatory, antianalgesic, and antipyretic activities. The main active compound of ... -
Apoptotic effects of some carbazole derivatives on lung carcinoma and glioma cell lines
(Springer Birkhauser, 2013)In this study, we aimed to study the apoptotic effects of 2-[(9-ethyl-9H-carbazol-3-yl)amino]-2-oxoethyl N,N-disubstituted dithiocarbamates on A549 lung carcinoma and C6 glioma cell lines. Cytotoxicity analyses of DNA ... -
Oxidative and inflammatory status and HDL functions of obese pre and post menopausal women
(Walter De Gruyter GMBH, 2014)Objective: Obesity and age related vascular changes coupled with the effect of estrogen withdrawal increases predisposition to atherosclerosis in postmenopausal women. But the functions of high density lipoprotein (HDL) ... -
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
(Bentham Science Publ LTD, 2017)Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines
(Bentham Science Publ LTD, 2017)Background: A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. Objective: In the present work, it ... -
In vitro effects of alpha-tocopherol and ascorbic acid on antioxidant characteristics of HDL
(Turkish Biochem Soc, 2011)Aim: High density lipoprotein (HDL) retards accumulation of proinflammatuar oxidized phospholipids in low density lipoproteins (LDL) and have a capacity on inhibition of oxidative modification. These antioxidant and ... -
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors
(Academic Press Inc Elsevier Science, 2019)The synthesis, characterization and biological evaluation of a series of novel N-substituted phthalazine sulfonamide (5a-1) are disclosed. Phthalazines which are nitrogen-containing heterocyclic compounds are biologically ... -
Inhibition effects of quinones on aldose reductase: Antidiabetic properties
(Elsevier, 2019)Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a ... -
Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity
(Springer, 2019)Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic complications. Here, AR was purified from sheep kidney ... -
Inhibition effects of pesticides on glutathione-S-transferase enzyme activity of Van Lake fish liver
(Wiley, 2018)Glutathione-S-transferases (GSTs) have a function in xenobiotic metabolism. They are a significant multifunctional family with a wide variety of catalytic activities. In the current study, we determined in vitro inhibition ... -
Evaluation of chalcones as inhibitors of glutathione S-transferase
(Wiley, 2018)Glutathione S-transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play an important role in cellular signaling. In the present study, potential inhibition effects of chalcones were ... -
Synthesis and bioactivity of several new hetaryl sulfonamides
(Taylor & Francis LTD, 2017)1-(4-Methylsulfonyl)-2-thione-4-aryl-5-Z-6-methyl and oxyalkyl-imidazoles were synthesized from different tetrahydropyrimidinethiones and aryl sulfonyl chloride. These compunds were tested for metal chelating effects and ... -
Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies
(Taylor & Francis LTD, 2019)Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an ... -
Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study
(Taylor & Francis LTD, 2017)Aldose reductase (AR) inhibitors have vital importance in the treatment and prevention of diabetic complications. In this study, rat kidney AR was purified 19.34-fold with a yield of 3.49% and a specific activity of 0.88 ... -
Antiepileptic drugs: Impacts on human serum paraoxonase-1
(Wiley, 2017)Serum paraoxonase (PON1) is a key enzyme related to high-density lipoprotein (HDL)-cholesterol particle. It can prevent the oxidation of low-density lipoprotein (LDL) and HDL. The present article focuses on the in vitro ...