Ara
Toplam kayıt 106, listelenen: 61-70
Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2014)
N'-(3,4-Diarylthiazol-2(3H)-ylidene)-2-(arylthio)acetohydrazides were synthesized and evaluated for their antimicrobial activity and cytotoxicity against NIH/3T3 cells. Compound 22 bearing 1-phenyl-1H-tetrazole and ...
The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics
(Tubitak Scientific & Technical Research Council Turkey, 2015)
Background/aim: Hypercholesterolemia is characterized by changes in lipid profile, nitric oxide pathway, and oxidative stress markers, but functions of high-density lipoprotein (HDL) were not well established in ...
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines
(2011)
Fenolik bir monoterpen olan karvakrol kekik bitkisinde bulunmaktadır ve besinlerde baharat olarak kullanılmaktadır. Bu çalışmanın amacı, karvakrol’ün H-ras transform edilmiş 5RP7 ve N-ras transform edilmiş CO25 hücreleri ...
Phenolic compounds: The inhibition effect on polyol pathway enzymes
(Elsevier Ireland LTD, 2017)
The polyol pathway called as sorbitol way is a small part of glycose metabolism. The pathway is regarded as an important element in the pathogenesis of various diabetic complications in individuals with diabetes mellitus. ...
A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells
(Turkish Pharmacists Assoc, 2019)
Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt. Materials ...
Effects of fibronectin and type IV collagen on osteosarcoma cell apoptosis
(Natl Inst Science Communication-Niscair, 2013)
The aims of this study are the investigation of the effects of fibronectin and type IV collagen extracellular matrix proteins and the role of caspase-3 and -9 on cis-platin induced U2-OS apoptosis were studied. First the ...
The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats
(Academic Journals, 2012)
The objective of this study was to determine the effects of metformin treatment and exercise intervention on lipid metabolism, nitric oxide (NO), nitric oxide synthase (NOS) and glucose levels in streptozotocin-nicotinamide ...
Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity
(Springer, 2019)
Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic complications. Here, AR was purified from sheep kidney ...
Modification of intracellular free calcium in cultured F2408 embryo fibroblasts by 3-sub substituted-2-thiohydantoin derivatives
(Wiley, 2004)
3-substituted-2-thiohydantoin derivatives were synthesized and their Structures elucidated by IR, H-1-NMR spectroscopy and elemental analysis. The cytotoxicity of the 2-thiohydantoin derivatives to rat embryo fibroblasts ...
Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies
(Taylor & Francis LTD, 2019)
Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an ...