Güncel Gönderiler: Analitik Kimya Anabilim Dalı
Toplam kayıt 131, listelenen: 101-120
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Determination of Ochratoxin-A in the brain microdialysates and plasma of awake, freely moving rats using ultra high performance liquid chromatography fluorescence detection method
(Elsevier, 2019)In this study, a simple, efficient and rapid Ultra High Performance Liquid Chromatography method with fluorescence detection (UHPLC-FLD) has been developed and validated for the determination of Ochratoxin-A (OTA) in rat ... -
A novel dilute and shoot HPLC assay method for quantification of irbesartan and hydrochlorothiazide in combination tablets and urine using second generation C-18-bonded monolithic silica column with double gradient elution
(Elsevier Science BV, 2014)Irbesartan (IRB) and hydrochlorothiazide (HCT) are angiotensin-ll receptor antagonist and thiazide-class diuretic compounds, respectively, which are in use in the treatment of hypertension. A novel diluteand-shoot HPLC ... -
Modulation of Corpus Striatal Neurochemistry by Astrocytes and Vasoactive Intestinal Peptide (VIP) in Parkinsonian Rats
(Humana Press Inc, 2016)The neurotoxin 6-hydroxydopamine (6-OHDA) is widely used in animal models of Parkinson's disease. In various neurodegenerative diseases, astrocytes play direct, active, and critical roles inmediating neuronal survival and ... -
The effect of pea (Pisum sativum L.)-originated asparaginase on acrylamide formation in certain bread types
(Wiley-Blackwell Publishing, Inc, 2010)P>The aim of this study was to investigate the effect of pea (Pisum sativum L.)-originated asparaginase on acrylamide formation in white wheat, wheat bran and whole-grain wheat breads. Two-day germinated pea flour was used ... -
Determination of Iloperidone in Pharmaceuticals by Validated High-Performance Liquid Chromatography
(Taylor & Francis Inc, 2018)Iloperidone is an antipsychotic drug used for treatment of acute schizophrenia in adults. In this study, a simple and specific method was developed for determination of iloperidone in tablets. The separation was performed ... -
A Stability Indicating Ion-Pair Lc Method for the Determination of Asenapine in Pharmaceuticals
(Soc Chilena Quimica, 2017)In this study, a new, simple and specific stability indicating ion-pair LC method was developed and fully validated for the determination of asenapine in tablets. The analysis was performed on an Agilent Eclipse XDB-C8 ... -
Preparation and Characterization of Rivaroxaban Nanocrystals Prepared by Combination of Wet Ball Milling and High Pressure Homogenization Methods
(Colegio Farmaceuticos Provincia De Buenos Aires, 2018)The objectives of this study were to develop rivaroxaban (RXB) nanocrystals by combination of wet ball milling and high-pressure homogenization, and to increase the solubility and dissolution rate of RXB. A new nanocrystal ... -
Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
(MDPI, 2017)In the present work, 14 new 1-substituted-2-phenylhydrazone derivatives were synthesized to evaluate their inhibitory activity against hMAO enzymes. The structures of the newly synthesized hydrazones 2a-2n were characterized ... -
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the recent works, it was shown that numerous thiazolylhydrazine derivatives display hMAO inhibitory activity in the range of micromolar concentration. Hence, in the present study a new series of new thiazole-hydrazines ... -
Development of Validated and Stability-Indicating LC-DAD and LC-MS/MS Methods for Determination of Avanafil in Pharmaceutical Preparations and Identification of a Novel Degradation Product by LCMS-IT-TOF
(MDPI, 2018)Avanafil (AVA), one of the most effective drugs prescribed for erectile dysfunction, is a pyrimidine-derivative PDE5 inhibitor. In the current work, new LC methods were developed and validated for quantitative determination ... -
Synthesis, Molecular Docking Studies, and Antifungal Activity Evaluation of New Benzimidazole-Triazoles as Potential Lanosterol 14 alpha-Demethylase Inhibitors
(Hindawi LTD, 2017)Due to anticandidal importance of azole compounds, a new series of benzimidazole-triazole derivatives(5a-5s) were designed and synthesized as ergosterol inhibitors. Thechemical structures of the target compounds were ... -
Validated Method for the Determination of Piroxicam by Capillary Zone Electrophoresis and Its Application to Tablets
(Hindawi Publishing Corporation, 2014)Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination of piroxicam in tablets. The separation of piroxicam was conducted in a fused-silica capillary by using ... -
The Effects of Vasoactive Intestinal Peptide on Duramater Nitric Oxide Levels and Vessel-Contraction Responses At Sympathectomized Rats
(Churchill Livingstone, 2009)… -
A Simple and Specific Hplc Method for the Determination of Atomoxetine in Pharmaceuticals and Human Plasma
(Taylor & Francis Inc, 2010)A liquid chromatographic method has been described for the determination of atomoxetine in pharmaceuticals and human plasma. Plasma samples were analyzed after a simple, one step protein precipitation with methanol, and ... -
Chemometrically assisted optimization and validation of a new HPLC method for the determination of paliperidone in pharmaceuticals
(Taylor & Francis Inc, 2018)Paliperidone is an antipsychotic drug, which is used for the acute and maintenance treatment of schizophrenia. In this study, a new method was developed for the determination of Paliperidone in its extended-release tablets. ... -
The Effects of Vasoactive Intestinal Peptide on Dura Mater Nitric Oxide Levels and Vessel-Contraction Responses in Sympathectomized Rats
(Humana Press Inc, 2010)Nitric oxide (NO) and neurogenic inflammation in dura mater due to nociceptor activation has been implicated for pathophysiology of primary headache disorders. Development of migraine has also been observed in patients ... -
Comparative study of different chemistries and particle properties, high-performance liquid chromatography stationary phases in separation of escitalopram oxalate and its impurities in different pharmaceutical dosage forms
(Wiley-V C H Verlag GMBH, 2019)The liquid chromatographic separation performance of 12 different columns was evaluated for the estimation of the escitalopram oxalate and six of its impurities in different pharmaceutical formulations. All columns exhibited ... -
A novel RP-HPLC method for simultaneous determination of potassium sorbate and sodium benzoate in soft drinks using C-18-bonded monolithic silica column
(Wiley Periodicals, Inc, 2011)Potassium sorbate and sodium benzoate are food additives that are generally employed for prevention of food spoilage originating from bacteria, molds or yeasts. Although these compounds were generally recognized as safe ...
