Kurum Yazarı "Temel, Halide Edip" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Apoptotic effects of some carbazole derivatives on lung carcinoma and glioma cell lines
Çiftçi, Gülsen Akalın; Temel, Halide Edip; Yıldırım, Şafak Ulusoylar; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Genç, Lütfi (Springer Birkhauser, 2013)In this study, we aimed to study the apoptotic effects of 2-[(9-ethyl-9H-carbazol-3-yl)amino]-2-oxoethyl N,N-disubstituted dithiocarbamates on A549 lung carcinoma and C6 glioma cell lines. Cytotoxicity analyses of DNA ... -
Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
Yurttaş, Leyla; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Sağlık, Begüm Nurpelin; Demir, Bahar; Levent, Serkan (Bentham Science Publ LTD, 2017)Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ... -
Butrylcholinesterase Activity in Chronic Liver Disease Patients and Correlation with Child-Pugh Classification and MELD Scoring System
Temel, Halide Edip; Temel, Tuncer; Cansu, Dondu Üsküdar; Özakyol, Ayşegül (Clin Lab Publ, 2015)Background: After 40 years since establishment of Child-Pugh staging, 14 years since establishment of MELD scoring system, and 25 years since establishment of King's College Criteria, there is still a search for more ... -
Chemical characterization and anticholinesterase effects of essential oils derived from Salvia species
Temel, Halide Edip; Demirci, Betül; Demirci, Fatih; Celep, Ferhat; Kahraman, Ahmet; Doğan, Musa; Başer, K. Hüsnü Can (Taylor & Francis Inc, 2016)Inhibitory effect of Salvia species herbal preparations on acetylcholinesterase (AChE) and butylcholinesterase (BuChE) activitiy may contribute to regulation of cognitive performance and impaired cholinergic functions in ... -
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
Çiftçi, Gülsen Akalın; Altıntop, Mehlika Dilek; Temel, Halide Edip; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ... -
Effect of alpha lipoic acid and silymarin on bladder outlet obstruction
Yıldırım, Abidin; Başesikoğlu, Barbaros; Temel, Halide Edip; Erkasap, Nilüfer; Yenilmez, Aydın; Uslu, Sema; Dönmez, Turgut (Spandidos Publ LTD, 2013)The aim of the present study was to determine whether the treatment of obstructed rat bladders with alpha lipoic acid (ALA) and silymarin reverses the biochemical and physiological responses to bladder outlet obstruction ... -
Effects of acetylsalicylate overdose on lipopolysaccharide-induced lung injury in rats: the role of the VEGF
Akyüz, Fahrettin; Aydın, Özlem; Aydın, Tayfun; Tekin, Neslihan; Temel, Halide Edip; Burukoğlu, Dilek; Aral, Erinç (Turkish Biochem Soc, 2012)Aim: Vascular endothelial growth factor production is decreased depending on the alveolar epithelial cell damage. Acute over expression of vascular endothelial growth factor in lung tissue contributes to the formation ... -
Effects of combination of p-dimethylaminoazobenzene and dioxin on serum lipid profile
Objective: The liver cancer initiator p-dimethylaminoazobenzene and the potent liver promoter Dioxin are the environmental pollutants that people may be exposed to those in their daily lives. Butyrylcholinesterase is a ... -
Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome
Uslu, S.; Özçelik, E.; Kebapçı, N.; Temel, Halide Edip; Demirci, Fatih; Ergün, Bülent; Demirüstü, C. (Springer London LTD, 2016)Background Elevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase ... -
The impact of klotho gene polymorphisms on urinary tract stone disease
Gürel, Abdullah; Ure, Iyimser; Temel, Halide Edip; Çilingir, Oğuz; Uslu, Sema; Celayir, Mehmet Fatih; Başesikoğlu, Ali Barbaros (Springer, 2016)To investigate the effect of klotho gene and beta-glucuronidase activity on stone formation in patients with urinary tract stone disease (UTSD). A total of 103 patients with UTSD and 102 controls with no specific urolithiasis ... -
New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation
Turan, Gülhan; Yurttaş, Leyla; Tabbi, Aouatef; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Kaplancıklı, Zafer Asım (MDPI AG, 2018)In this study, novel N-(3-cyclohexyl/phenyl-4-(substituted phenyl)thiazole-2(3H)-ylidene)-2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetohydrazide (4a-4k) derivatives were synthesized and their anticancer potency were ... -
NO levels in diabetes mellitus: Effects of l-NAME and insulin on LCAT, Na+/K+ ATPase activity and lipid profile
Tekin, Neslihan; Akyüz, F.; Temel, Halide Edip (Elsevier Ltd, 2011)Objectives: Diabetes mellitus (DM) is a chronic disease and one of the most important health problems. Several factors may be responsible for the complications of diabetes mellitus including alterations in the activities ... -
Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
Yurttaş, Leyla; Ertaş, Merve; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Demirayak, Şeref (University of Istanbul, 2017)In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against ... -
Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Walter De Gruyter GMBH, 2017)Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme ... -
Oxidative stress-mediated myrocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats
Saraçoğlu, Ahmet; Temel, Halide Edip; Ergün, Bülent; Çolak, Ömer (Taylor & Francis Inc, 2009)In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were ... -
Rhanterium epapposum Oliv. essential oil: Chemical composition and antimicrobial, insect-repellent and anticholinesterase activities
Demirci, Betül; Yusufoğlu, Hasan Soliman; Tabanca, Nurhayat; Temel, Halide Edip; Bernier, Ulrich R.; Agramonte, Natasha M.; Demirci, Fatih (Elsevier Science BV, 2017)The essential oil (EO) of the aerial parts of Rhanterium epapposum Oliv. (Asteraceae), was obtained by hydrodistillation. The oil was subsequently analyzed by both GC-FID and GC-MS, simultaneously. Forty-five components ... -
Serum Thrombopoietin Levels and Its Relationship With Thrombocytopenia in Patients With Cirrhosis
Temel, Tuncer; Cansu, Dondu Üsküdar; Temel, Halide Edip; Özakyol, Ayşegül Harmancı (Kowsar Publ, 2014)Background: Patients with cirrhosis usually have thrombocytopenia in discrete levels. The mechanism of thrombocytopenia is thought as splenic sequestration and destruction of platelets, impaired bone marrow generation and ... -
Supplemental Carvacrol Can Reduce the Severity of Inflammation by Influencing the Production of Mediators of Inflammation
Kara, Mehmet; Uslu, Sema; Demirci, Fatih; Temel, Halide Edip; Baydemir, Canan (Springer/Plenum Publishers, 2015)Carvacrol (CVC) is a monoterpenic phenol, which is present in the essential oil of various plants. It has been widely used both as antibacterial feed additive and food preservative. Therefore, our objective was to evaluate ... -
Synthesis and Anticholinesterase Activity and Cytotoxicity of Novel Amide Derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Temel, Halide Edip; Akalın Çiftçi, Gülsen (Wiley-V C H Verlag GMBH, 2012)In the present study, some amide derivatives were synthesized and their potential anticholinesterase properties were investigated. N-(Benzothiazol-2-yl)-2-[(5-amino/methyl-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives ... -
Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors
Yurttaş, Leyla; Kaya Çavuşoğlu, Betül; Çiftçi, Gülsen Akalın; Temel, Halide Edip (Bentham Science Publ LTD, 2018)Background: 1,3,4-Oxadiazoles have been known with a wide variety of pharmacological activities including anticancer activity. Objective: In this study, novel 2,5-disubstituted 1,3,4-oxadiazole derivatives were synthesized ...