Kurum Yazarı "Sivas, Hülya" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Activated N-ras oncogene inhibits the expression of PDGF-beta receptor in myoblast cells
Sivas, Hülya; Griffiths, S. L.; Gibson, I (Inst Exp Pathol Oncol Radiobiol, 2002)By RT-PCR technique mRNA levels of platelet-derived growth factor type-beta receptor (PDGF-beta-R) and MyoD1 in a myoblast cell line carrying human N-ras oncogene have been investigated. After dexamethasone treatment an ... -
Biological activities of Cu(II) and Hg(II) complexes of a heptadentate Schiff base ligand
Ergene, Emel; Sivas, Hülya; Benkli, Kadriye (Tubitak Scientific & Technical Research Council Turkey, 2010)Two metal complexes were synthesized as [Hg(L)](ClO4)(2) and [Cu(L)](ClO4), by the template reaction between 2,6-bis(2-aminothiophenoxymethyl)pyridine and 2,2'-bipyridine-6,6'-dicarboxaldehyde in the presence of Hg(II) and ... -
Biological assays on the effects of Acra3 peptide from Turkish scorpion Androctonus crassicauda venom on a mouse brain tumor cell line (BC3H1) and production of specific monoclonal antibodies
Çalışkan, Figen; Ergene, Emel; Sögüt, İbrahim; Hatipoğlu, İbrahim; Basalp, Aynur; Sivas, Hülya; Kanbak, Güngör (Pergamon-Elsevier Science LTD, 2013)Constitutes of the venom scorpion are a rich source of low molecular mass peptides which are toxic to various organisms, including man. Androctonus crassicauda is one of the scorpions from the Southeastern Anatolia of ... -
Characterisation of dorylaion (Turkey) pottery sherds from Hittite period
Kara, Alpagut; Darga, M; Ay, Nuran; Ayaş, E; Sivas, Taciser; Sivas, Hülya (Trans Tech Publications LTD, 2004)In this study, representative samples were taken from eleven pottery sherds of Hittite period recovered during the archaeological excavations of different years in the ancient city Dorylaion, which is nowadays called as ... -
Composition, antimicrobial activity and in vitro cytotoxicity of essential oil from Cinnamomum zeylanicum Blume (Lauraceae)
Ünlü, Mehmet; Ergene, Emel; Ünlü, Gülhan Vardar; Sivas, Hülya; Vural, Nilüfer (Pergamon-Elsevier Science LTD, 2010)The essential oil from the bark of Cinnamomum zeylanicum Blume was analyzed by GC-MS and bioassays were carried out. Nine constituents representing 99.24% of the oil were identified by GC-MS. The major compounds in the oil ... -
Cytotoxicity of Plumbagin, Rapanone and 12 other naturally occurring Quinones from Kenyan Flora towards human carcinoma cells
Kuete, Victor; Omosa, Leonidah K.; Tala, Viviane R. Sipowo; Midiwo, Jacob O.; Mbaveng, Armelle T.; Swaleh, Sauda; Sivas, Hülya (Bmc, 2016)Background: Cancer is a major public health concern globally and chemotherapy remains the principal mode of the treatment of various malignant diseases. Methods: This study was designed to investigate the cytotoxicity of ... -
Cytotoxicity of seputhecarpan D, thonningiol and 12 other phytochemicals from African flora towards human carcinoma cells
Kuete, Victor; Ngnintedo, Dominique; Fotso, Ghislain W.; Karaosmanoğlu, Oğuzhan; Ngadjui, Bonaventure T.; Keumedjio, Felix; Sivas, Hülya (Bmc, 2018)Background: Despite the remarkable progress in cancer therapy in recent years, this disease still remains a serious public health concern. The use of natural products has been and continues to be one of the most effective ... -
Cytotoxicity of the methanol extracts of Elephantopus mollis, Kalanchoe crenata and 4 other Cameroonian medicinal plants towards human carcinoma cells
Kuete, Victor; Fokou, Fabrice W.; Karaosmanoğlu, Oğuzhan; Beng, Veronique P.; Sivas, Hülya (Bmc, 2017)Background: Cancer still constitutes one of the major health concerns globally, causing serious threats on patients, their families, and the healthcare system. Methods: In this study, the cytotoxicity of the methanol extract ... -
Determination of genotoxic, antigenotoxic and cytotoxic potential of the extract from lichen Cetraria aculeata (Schreb.) Fr. in vitro
Sivas, Hülya; Seller, Zerrin; Tüylü, Berrin; Türk, A. O.; Barutca, B. (Wiley, 2008)Naturally occurring compounds can have protective effects towards mutagens and carcinogens as shown by numerous studies. In the present study, the genotoxic/antigenotoxic activities of the extract from lichen Cetraria ... -
Effects of carvacrol on sister chromatid exchanges in human lymphocyte cultures
İpek, E; Tüylü, Berrin; Sivas, Hülya (Springer, 2003)Carvacrol is a predominant aromatic compound in oil of oregano. It has naturally remarkable antibacterial, antiviral, antifungal and antiparasital effects. In this study, genotoxic and antigenotoxic activities of carvacrol ... -
Effects of fibronectin and type IV collagen on osteosarcoma cell apoptosis
Seller, Zerrin; Hatipoğlu, İbrahim; Sivas, Hülya; Ergene, Emel; Çiftçi, Gülsen Akalın (Natl Inst Science Communication-Niscair, 2013)The aims of this study are the investigation of the effects of fibronectin and type IV collagen extracellular matrix proteins and the role of caspase-3 and -9 on cis-platin induced U2-OS apoptosis were studied. First the ... -
The effects of n-ras oncogene expression on PDGF-BB stimulated responses in cultured mouse myoblasts
Sivas, Hülya; Griffiths, S. L.; Dawson, A. P.; Gibson, I. (1995)The role of the ras oncogene in the signalling pathway triggered by platelet-derived growth factor BB (PDGF-BB) has been investigated in a cell line which normally differentiates into myotubes. Following the activation of ... -
The effects of parasitism by the ectoparasitoid Bracon hebetor Say (Hymenoptera: Braconidae) on host hemolymph proteins in the Mediterranean flour moth Ephestia kuehniella Zeller (Lepidoptera: Pyralidae)
Altuntaş, Hülya; Kılıç, Ali Yavuz; Sivas, Hülya (Tubitak Scientific & Technical Research Council Turkey, 2010)Parasitism of lepidopteran larvae by braconid wasps has significant effects on host hemolymph proteins and the physiology of the host insect. In this study the post-parasitism effect's of a gregarious idiobiont ectoparasitoid ... -
Genotoxicity and antigenotoxicity of Origanum oil and carvacrol evaluated by Ames Salmonella/microsomal test
İpek, E; Sivas, Hülya; Okay, S; Tüylü, Berrin; Kürkçüoğlu, Mine; Başer, K. Hüsnü Can (Elsevier Sci LTD, 2005)This study evaluates the genotoxic and antigenotoxic effects of the essential oil of Origanum onites L. and carvacrol that are used in medicine, flavouring of food and crop protection by Ames Salmonella/microsomal test. ... -
Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells
Karaosmanoğlu, Oğuzhan; Banerjee, Sreeparna; Sivas, Hülya (Springer, 2018)Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Complete epithelial to mesenchymal transition (EMT) has long been considered as a crucial step for metastasis initiation. It ... -
In vitro cytotoxicity of compounds isolated from Desbordesia glaucescens against human carcinoma cell lines
Kuete, Victor; Mafodong, F. L. Dongmo; Çelik, I.; Fobofou, S. A. T.; Ndontsa, B. L.; Karaosmanoğlu, Oğuzhan; Sivas, Hülya (Elsevier Science BV, 2017)Malignancies constitute a global health concern and chemotherapy remains the main mode of treatment. The present study was designed to evaluate the cytotoxicity of 8 compounds from Desbordesia glaucescens namely ... -
Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene
Sivas, Hülya; Seller, Zerrin; Başer, K. Hüsnü Can (Urban & Fischer Verlag, 2003)Monoterpenes are dietary components found in the essential oils of a wide variety of plants. A number of these monoterpenes have antitumor activity. We have investigated the effects of carvacrol obtained by fractional ... -
Investigation of cytogenetic effects of 2, 4, 5 triphenyl imidazole by rat bone marrow micronucleus test
Sivas, Hülya; Saleh, K.; Canbek, M. (2001)The cytogenetic effects of 2, 4, 5 triphenyl imidazole on the micronucleus formation were investigated in rats. Increasing doses of the substance were injected i.p. into Wistar rats and polychromatic and normochromatic ... -
Investigation of genotoxic effects of paraben in cultured human lymphocytes
Bayulken, Devrim Güzel; Tüylü, Berrin; Sinan, Handan; Sivas, Hülya (Taylor & Francis LTD, 2019)Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the ... -
Mutagenicity assay in Salmonella for thirteen 2-substituted-1H-phenanthro (9,10-d) imidazoles
Sivas, Hülya; Ergene, E; Tüylü, Berrin (Taylor & Francis LTD, 2003)Some 2-substituted-1H-phenanthro [9,10-d] imidazole compounds synthesized as a predrugs were tested in mutagenicity assays in Salmonella strains TA97, TA98, and TA100 using a plate incorporation assay both with and without ...