Kurum Yazarı "Seller, Zerrin" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Anticancer Activity of Some Bisbenzimidazoles
Işıkdağ, İlhan; Özkay, Yusuf; İncesu, Zerrin; Akalın Çiftçi, Gülsen (Verlag Z Naturforsch, 2011)The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bishenzimidazole derivatives are important compounds known as DNA topoisomerase 1 inhibitors. In the present study, some ... -
Antimicrobial and anticancer effects of some 2-(substitutedsulfanyl)-N-(5-methyl-isoxazol-3-yl)acetamide derivatives
Özkay, Yusuf; Seller, Zerrin; Önder, Nur İpek; Tunalı, Yağmur; Karaca Gencer, Hülya; Işıkdağ, İlhan; Uçucu, Ümit (Springer Birkhauser, 2013)In the present study, some isoxazole-(benz)azole derivatives (3a-3j) were synthesized by considering antimicrobial and anticancer potencies of azole compounds. Chemical structures of obtained compounds (3a-3j) were confirmed ... -
Antiproliferative effects of some N-benzylideneanilines
Özkay, Yusuf; Seller, Zerrin; Işıkdağ, İlhan; Yesilkaya, Mehmet (John Wiley & Sons LTD, 2008)A series of Schiff bases including N-benzylideneaniline (NBA) nuclei were prepared. The chemical products obtained were characterized by mass spectometry (APCI), H-1 NMR, and IR spectroscopy in order to seek their cytotoxic ... -
Apoptotic effects of epsilon-viniferin in combination with cis-platin in C6 cells
Özdemir, Filiz; Apaydın, Elif; Önder, Nur İpek; Şen, Mesut; Ayrim, Aysun; Öğünç Keçeci, Yüksel; Seller, Zerrin (Springer, 2018)Glioblastoma (GBM) is one of the most common and lethal forms of primary brain tumors in human adults. Treatment options are limited, and in most cases ineffective. Natural products are sources of novel compounds endowed ... -
Apoptotic effects of some thiohydantoin derivatives [Bazi{dotless} Tiyohidantoin Türevlerinin Apoptotik Etkileri]
Seller, Zerrin; Akalın Çiftçi, Gülsen (2010)Objectives: The aim of this study is to investigate the effects of newly synthesized 3-phenly-and 3-(4-methoxyphenyl)-2-thiohydantoin derivatives on 5RP7 ve CO25 cell apoptosis. Methods and Materials: Thiohydantoin derivatives ... -
Calcium Mobilization and Inhibition of Akt Reduced the Binding of PEO-1 Cells to Fibronectin
Sarı Kılıçaslan, Seda Mehtap; Ayrim, Aysun; Apaydın, Elif; Seller, Zerrin (Turkish Pharmacists Assoc, 2018)Objectives: To investigate the effects of intracellular calcium (Ca2+) mobilization, beta-catenin and Akt signal pathways after the binding of metastatic ovarian cells to fibronectin. Materials and Methods: The expression ... -
Cytotoxic effects of some perimidine derivatives on F2408 and 5Rp7 cell lines
Işıkdağ, İlhan; Seller, Zerrin; Gülnaz, D.; Özkay, Yusuf (2008)In this study twenty perimidine derivatives were prepared in order to seek their cytotoxic and antiproliferative effects on normal rat embryo fibroblast (F2408) and carcinogenic rat embryo fibroblast (5RP7) cell lines. ... -
Determination of apoptosis on fibronectin and collagen iv adhered 5RP7 cells [Fi·bronekti·n ve kolajen iv'e bagli 5RP7 hücreleri·nde apoptozun beli·rlenmesi·]
Seller, Zerrin; Fırat, Ç.; Aydoğdu, Ş. (2009)Extracellular proteins such as fibronectin and collagen IV have a function in many cellular events such as cell growth, cell differentiation, tissue formation, cell adhesion, wound healing as well as have an important ... -
Determination of Cytotoxic and Anticandidal Activities of Three Verbascum L. Species from Turkey: V-cheiranthifolium Boiss. var. asperulum (Boiss.) Murb. Monorg., V-pycnostachyum Boiss. & Heldr and V-orgyale Boiss. & Heldr
Küçük, Sevim; Özdemir, Filiz; İşcan, Gökalp; Seller, Zerrin (Turkish Pharmacists Assoc, 2016)Purpose of this study is to determine of cytotoxic and anticandidal activities of Verbascum cheiranthifolium Boiss. var. asperulum (Boiss.) Murb. Monorg., Verbascum pynostachyum Boiss. & Heldr and Verbascum orgyale Boiss. ... -
Determination of genotoxic, antigenotoxic and cytotoxic potential of the extract from lichen Cetraria aculeata (Schreb.) Fr. in vitro
Sivas, Hülya; Seller, Zerrin; Tüylü, Berrin; Türk, A. O.; Barutca, B. (Wiley, 2008)Naturally occurring compounds can have protective effects towards mutagens and carcinogens as shown by numerous studies. In the present study, the genotoxic/antigenotoxic activities of the extract from lichen Cetraria ... -
Determination of Phenolic Compounds, Cytotoxic, Antioxidant and Anticandidal Effects of Tribulus Terrestris L. (Zygophyllaceae)
Küçük, Sevim; Göğer, Fatih; İşcan, Gökalp; Özdemir, Filiz; Kırımer, Neşe; Seller, Zerrin (Parlar Scientific Publications (PSP), 2017)This study was investigated the potential cytotoxic, antioxidant and anticandidal activities of T terrestris in vitro. Both the fruit and aerial parts of the T terrestris extract showed a significant cytotoxic effects in ... -
Direct and protective effects of single or combined addition of vincristine and epsilon-viniferin on human HepG2 cellular oxidative stress markers in vitro
Tarhan, Seda; Özdemir, Filiz; Seller, Zerrin; Demirkan, Emine Sutken (Springer, 2016)The objective of this study is to examine the direct effects of low doses and high doses of epsilon-viniferin, a substance known to be an antioxidant, and vincristine sulphate, a chemotherapeutic agent, alone and in ... -
The effects of 1,3 bis (heteroaryl substitued) benzene derivatives on apoptosis of N-ras transformed mouse skeletal muscle cell [1,3-Bi·s (heteroari·l sübsti·tüe) benzen türevleri·ni·n N-ras transform fare kasi hücre apoptozu üzeri·ne etki·leri·]
Akalın Çiftçi, Gülsen; Seller, Zerrin (2005)Increasing number of the cells, results of excess divicing of the cells, is balanced by apoptosis which causes elimination of old cells and unfunctional cells. Apoptosis is a programmed cell death obtaining this balance. ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines [Karvakrol'ün H-ras ve N-ras transform hücre apoptozu üzerine etkileri]
Akalın Çiftçi, Gülsen; Seller, Zerrin (2011)Carvacrol is a phenolic monoterpen found in Thyme plant which is used as a source of flavour in food. The aim of this study was to investigate apoptotic effects of carvacrol on H-ras transformed 5RP7 and N-ras transformed ... -
Effects of fibronectin and type IV collagen on osteosarcoma cell apoptosis
Seller, Zerrin; Hatipoğlu, İbrahim; Sivas, Hülya; Ergene, Emel; Çiftçi, Gülsen Akalın (Natl Inst Science Communication-Niscair, 2013)The aims of this study are the investigation of the effects of fibronectin and type IV collagen extracellular matrix proteins and the role of caspase-3 and -9 on cis-platin induced U2-OS apoptosis were studied. First the ... -
The effects of some phenanthroline ruthenium (II) complexes on A549 cell proliferation [Bazi{dotless} fenantrolin rutenyum (II) komplekslerinin a549 hücre çogalmasi{dotless} üzerine etkileri]
In recent years, ruthenium (II) complexes have increasingly attracted the interest of researchers because of their high antitumor activities that are usually related to DNA binding. Here, we synthesized two ruthenium (II) ... -
Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene
Sivas, Hülya; Seller, Zerrin; Başer, K. Hüsnü Can (Urban & Fischer Verlag, 2003)Monoterpenes are dietary components found in the essential oils of a wide variety of plants. A number of these monoterpenes have antitumor activity. We have investigated the effects of carvacrol obtained by fractional ... -
Investigation of signal transduction pathways involved in melanoma cell spreading
Seller, Zerrin; Hart, I. R. (2000)Integrins are a major family of heterodimeric adhesion receptors that are responsible for anchoring cells to extracellular matrix and they also can initiate intracellular signal pathways. Here parental and ?4-expressing ... -
Modification of intracellular free calcium in cultured F2408 embryo fibroblasts by 3-sub substituted-2-thiohydantoin derivatives
Seller, Zerrin; Benkli, Kadriye; Akalın, G; Kaplancıklı, Zafer Asım (Wiley, 2004)3-substituted-2-thiohydantoin derivatives were synthesized and their Structures elucidated by IR, H-1-NMR spectroscopy and elemental analysis. The cytotoxicity of the 2-thiohydantoin derivatives to rat embryo fibroblasts ... -
The study on the synthesis and the effects on the intracellular calcium of some 9-substituted-phenanthrene derivatives.
Işıkdağ, İlhan; Meriç, Asiye; Gÿnes, S.; Seller, Zerrin (2004)Some 9-(substituted with heteroaryl)-phenanthrene compounds, polycyclic aromatic hydrocarbons (PAH), were obtained by two different methods. In the first method, 9-phenanthraldehyde was reacted with some dion compounds ...