Kurum Yazarı "Demirayak, Şeref" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Anticancer and anti-HIV activities of some pyrido/pyrazino- benzimidazole derivatives
Demirayak, Şeref; Mohsen, U. A. (1998)In this study the anticancer and anti-HIV activities of some 1-hydroxy- 3-arylpyrido[1,2-a] benzimidazole and 1-substituted 3-arylpyrazino [1,2-a] benzimidazole derivatives derived from 1-(2-aryl-2-oxoethyl)-2- ... -
Antimicrobial activity evaluation of new 1,3,4-oxadiazole derivatives
Yurttaş, Leyla; Bülbül, E. F.; TekinKoca, Sabiha; Demirayak, Şeref (University of Istanbul, 2017)In this study, we have synthesized seven novel 2-[(5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-yl)thio]-N-(6-substituted benzothiazol-2-yl)acetamide derivatives (4ag) starting from ethyl 4-chlorophenyl acetate. The antimicrobial ... -
Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles
Giray, B.; Yurttaş, Leyla; Şahin, Z.; Berk, B.; Demirayak, Şeref (İstanbul Medipol University, 2019)Thiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. In recent, third generation cephalosporins include thiazole ring system. In this study, we synthesized 33 piperazine ... -
Benzimidazol derivatives: Synthesis, antibacterial activity and QSARs of some 2-alkyl-5-chloro-benzimidazoles
Işıkdağ, İlhan; Uçucu, Ümit; Demirayak, Şeref; Çakır, B. (1989)[No abstract available] -
Crystal structure of [1-(1H-benzoimidazol-2-yl)-ethanone thiosemicarbazone]2nickel, [C20H22N10S2Ni]
Sarı, Mehmet; Poyraz, M.; Demirayak, Şeref; Büyükgüngör, Orhan (Japan Society for Analytical Chemistry, 2005)The title compound, [C20H22N10S2Ni], crystallizes in the triclinic space group P1 with cell parameters a = 10.9319(9)Å, b = 12.0083(9)Å, c = 13.4978(11)Å, ? = 87.057(7)°, ß = 85.841(7)°, ? = 63.820 (6), V = 1585.6(2)Å3, Z ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
Yurttaş, Leyla; Demirayak, Şeref; Çiftçi, Gülsen Akalın (Bentham Science Publ LTD, 2015)Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a ... -
Determination and evaluation of acid dissociation constants of some substituted 2-aminobenzothiazole derivatives
Öğretir, Cemil; Demirayak, Şeref; Tay, Naime Funda; Duran, M. (American Chemical Society, 2008)The acid dissociation constants of some 4- and/or 6-substituted 2-aminobenzothiazole and 4-substituted thiazole derivatives were determined spectroscopically. With the exception of a few, the first protonation was found ... -
A facile synthesis of 2-aryl-4,5-di(2-thienyl)imidazoles under microwave irradiation and their antimicrobial activities
In this study, some 2-aryl-4,5-dithienylimidazoles were synthesized by reacting di-(2-thienyl)ethandione and a suitable aromatic aldehyde in the presence of ammonium acetate in acetic acid. Either the classical reflux ... -
A facile synthesis of some thieno/furo-[2,3-d]pyrimidine-2-yl-thioacetic acid derivatives
Demirayak, Şeref; Mohsen, U. A. (HeteroCorporation, 2001)The reaction of 2-(?-chloroacetamido)-3-cyano-4,5-disubstituted thiophenes/furanes with ammonium thiocyanate in methanol or ethanol afforded methyl or ethyl (4-amino-5,6-disubstituted thieno/furo[2,3-d]-pyrimidine-2-yl)t ... -
In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells
Yurttaş, Leyla; Demirayak, Şeref; Ilgın, Sinem; Atlı Eklioğlu, Özlem (Pergamon-Elsevier Science LTD, 2014)A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis(4-subtituted phenyl)-1,2,4-triazin-3-yl) piperazin- ... -
Microwave supported synthesis of some novel 1,3-Diarylpyrazino[1,2-a] benzimidazole derivatives and investigation of their anticancer activities
Demirayak, Şeref; Kayagil, İsmail; Yurttaş, Leyla (Elsevier France-Editions Scientifiques Medicales Elsevier, 2011)The syntheses of 1,3-diarylpyrazino[1,2-a]benzimidazole derivatives and the investigation of their anticancer activities were studied. For this, 2-aryloylbenzimidazole derivatives were reacted with 2-bromoacetophenones in ... -
New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents
Demirayak, Şeref; Yurttaş, Leyla; Gündoğdu-Karaburun, Nalan; Karaburun, Ahmet Çağrı; Kayagil, İsmail (Elsevier Science BV, 2017)The synthesis of 3-[3/4-(2-aryl-2-oxoethoxy) arylidene] chroman/thiochroman-4-one derivatives (1-34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis ... -
Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
Yurttaş, Leyla; Ertaş, Merve; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Demirayak, Şeref (University of Istanbul, 2017)In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against ... -
Novel synthesis of some 2-(-heterocyclic) substituted benzimidazole derivatives
Demirayak, Şeref (1991)[No abstract available] -
Pyridine-substituted thiazolylphenol derivatives: Synthesis, modeling studies, aromatase inhibition, and antiproliferative activity evaluation
Ertaş, Merve; Şahin, Zafer; Berk, Barkın; Yurttaş, Leyla; Biltekin, Sevde N.; Demirayak, Şeref (Wiley-V C H Verlag GMBH, 2018)Drugs used in breast cancer treatments target the suppression of estrogen biosynthesis. During this suppression, the main goal is to inhibit the aromatase enzyme that is responsible for the cyclization and structuring of ... -
Quinazolinones, XVII1): Synthesis and Pharmacological Activities of Some Antipyryloxoalkylthioquinazolinones
Chinazolinone, 17. Mitt.1): Synthese und pharmakologische Wirksamkeit einiger Antipyryloxoalkylthiochinazolinone Copyright © 1990 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim -
Some 1-substituted 3-aryl-1,4-dihydro-1,2,4-triazino[4,3-a]- benzimidazoles and their vasodilatory activities
Demirayak, Şeref; Benkli, Kadriye; Karaburun, Ahmet Çağrı (Societa Chimica Italiana, 1997)In this study, some 1-substituted 3-aryl-1,4-dihydro-1,2,4- triazino[4,3-a]benzimidazole derivatives were synthesized, their structures were elucidated, and their vasodilatory activities were examined. It was found that ... -
Some 3-alkyl-6-(2-aryl-2-oxo-1-ethyl)-7-oxothiazolo [4,5-d]pyrimidin-2(3H)-thione derivatives and their antimicrobial activities
In this study, some 3-alkyl-6-(2-aryl-2-oxo-1-ethyl)-7-oxothiazolo [4,5-d]pyrimidin-2(3H)-thione derivatives have been synthesized by reacting 3-alkyl-7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thiones with various ?-bromoacetophenones. ... -
Some 6-substituted 3-aryl-7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thione derivatives and their antimicrobial activities
Demirayak, Şeref; Ali, Faten Dali; Osman, Baland Sirvan; Tunalı, Yağmur (Taylor & Francis LTD, 2007)In this study, 3-aryl-6-substituted thiazolopyrimidin-2(3H)-thione derivatives 4 and 6 have been synthesized by reacting thiazolopyrimidines 2 with omega-bromoacetophenone 3 and 2-chloro-N-(2-thiazolyl)acetamides 5. The ...