Kurum Yazarı "Beydemir, Şükrü" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity
Türkeş, Cüneyt; Demir, Yeliz; Beydemir, Şükrü (Springer, 2019)Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic complications. Here, AR was purified from sheep kidney ... -
Antiepileptic drugs: Impacts on human serum paraoxonase-1
Beydemir, Şükrü; Demir, Yeliz (Wiley, 2017)Serum paraoxonase (PON1) is a key enzyme related to high-density lipoprotein (HDL)-cholesterol particle. It can prevent the oxidation of low-density lipoprotein (LDL) and HDL. The present article focuses on the in vitro ... -
Antioxidant and Antiradical Properties of Selected Flavonoids and Phenolic Compounds
Huyut, Zubeyir; Beydemir, Şükrü; Gülçin, İlhami (Hindawi LTD, 2017)Phenolic compounds and flavonoids are known by their antioxidant properties and one of the most important sources for humans is the diet. Due to the harmful effects of synthetic antioxidants such as BHA and BHT, natural ... -
An approach to clarify the effect mechanism of glyphosate on body malformations during embryonic development of zebrafish (Daino rerio)
Sulukan, Ekrem; Köktürk, Mine; Ceylan, Hamid; Beydemir, Şükrü; Işık, Mesut; Atamanalp, Muhammed; Ceyhun, Saltuk Bugrahan (Pergamon-Elsevier Science LTD, 2017)In this study, it has been investigated that the effects of glyphosate, which is a herbicide within organophosphate and unselective widely used in agriculture on enzyme activity of carbonic anhydrase, production of reactive ... -
Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1
Alim, Zuhal; Kılıç, Deryanur; Köksal, Zeynep; Beydemir, Şükrü; Özdemir, Hasan (Wiley, 2017)Paraoxonase-1 (PON1) is an organophosphate hydrolyzer and antiatherogenic enzyme. Due to the PON1's crucial functions, inhibitors and activators of PON1 must be known for pharmacological applications. In this study, we ... -
The effects of some cephalosporins on acetylcholinesterase and glutathione S-transferase: an in vivo and in vitro study
Türkan, Fikret; Huyut, Zubeyir; Demir, Yeliz; Ertaş, Fatma; Beydemir, Şükrü (Taylor & Francis LTD, 2019)Background: Glutathione S-transferase (GST) and acetylcholinesterase (AChE) are important enzymes in the metabolism. GSTs are primarily available in phase II metabolism. AChE is vital for neurodegenerative disorders. ... -
Evaluation of chalcones as inhibitors of glutathione S-transferase
Özaslan, Muhammet Serhat; Demir, Yeliz; Aslan, Hatice Esra; Beydemir, Şükrü; Kufrevioğlu, Ömer İrfan (Wiley, 2018)Glutathione S-transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play an important role in cellular signaling. In the present study, potential inhibition effects of chalcones were ... -
Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies
Beydemir, Şükrü; Türkeş, Cüneyt; Yalçın, Ahmet (Taylor & Francis LTD, 2019)Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an ... -
In vitro toxicity effects of some insecticides on gilthead sea bream (Sparus aurata) liver glucose 6-phosphate dehydrogenase
Kırıcı, Muammer; Beydemir, Şükrü; Bülbül, Metin (Nobel Science and Research Center, 2016)In this study, effects of some insecticides (cypermethrin, deltamethrin, dichlorvos, imidacloprid and lambda-cyhalothrin) on glucose 6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+ oksidoreductase, EC 1.1.1.49; ... -
Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study
Alim, Zuhal; Kılınç, Namık; Şengül, Bülent; Beydemir, Şükrü (Taylor & Francis LTD, 2017)Aldose reductase (AR) inhibitors have vital importance in the treatment and prevention of diabetic complications. In this study, rat kidney AR was purified 19.34-fold with a yield of 3.49% and a specific activity of 0.88 ... -
Inhibition effects of pesticides on glutathione-S-transferase enzyme activity of Van Lake fish liver
Özaslan, Muhamnnet Serhat; Demir, Yeliz; Aksoy, Mine; Kufrevioğlu, Ömer İrfan; Beydemir, Şükrü (Wiley, 2018)Glutathione-S-transferases (GSTs) have a function in xenobiotic metabolism. They are a significant multifunctional family with a wide variety of catalytic activities. In the current study, we determined in vitro inhibition ... -
Inhibition effects of quinones on aldose reductase: Antidiabetic properties
Demir, Yeliz; Özaslan, Muhammet Serhat; Duran, Hatice Esra; Kufrevioğlu, Ömer İrfan; Beydemir, Şükrü (Elsevier, 2019)Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a ... -
Inhibition of Human Serum Paraoxonase-I with Antimycotic Drugs: In Vitro and In Silico Studies
Türkeş, Cüneyt; Beydemir, Şükrü (Humana Press Inc., 2019)Drugs show their pharmacological effects by inhibiting or activating enzymes. Therefore, enzyme inhibitors have an essential place in the drug design for numerous different sorts of diseases, i.e., cardiovascular, cancer, ... -
Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes
Huyut, Zubeyir; Beydemir, Şükrü; Gülçin, İlhami (Wiley, 2017)Carbonic anhydrases (CAs, E.C.4.2.1.1) play a critical role in many important physiological events and treatment of some diseases. Flavonoids or phenolic compounds have been discovered as novel CAs inhibitors instead of ... -
Inhibitory Effects of Usnic and Carnosic Acid on Some Metabolic Enzymes: An in vitro Study
Ceylan, Hamid; Demir, Yeliz; Beydemir, Şükrü (Bentham Science Publ LTD, 2019)Background: Natural products arc produced via primary and secondary metabolism in different organisms. The compounds obtained via secondary metabolism are not essential for the survival of the organism, but they can have ... -
The interactions of cephalosporins on polyol pathway enzymes from sheep kidney
Şengül, Bülent; Beydemir, Şükrü (Taylor & Francis LTD, 2018)Context: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine.Objective: An investigation of the effects on sheep renal aldose reductase ... -
Mechanism of capsaicin inhibition of aldose reductase activity
Alim, Zuhal; Kılınç, Namık; Şengül, Bülent; Beydemir, Şükrü (Wiley, 2017)Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive ... -
Oxidative stress and mRNA expression of acetylcholinesterase in the leukocytes of ischemic patients
Işık, Mesut; Beydemir, Şükrü; Yılmaz, Aslan; Naldan, Muhammet Emin; Aslan, Hatice Esra; Gülçin, İlhami (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)Background: Pathogenesis of ischemic brain injury is occurred by crucial metabolic reasons. For instance, oxidative stress from free radical generation is causing to the thrombotic cerebrovascular stroke. In this case, the ... -
Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney
Demir, Yeliz; Işık, Mesut; Gülçin, İlhami; Beydemir, Şükrü (Wiley, 2017)Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol accumulation during the hyperglycemia. The present article focuses on the role of phenol, pyrogallol, hydroquinone, resorcinol, ... -
Phenolic compounds: The inhibition effect on polyol pathway enzymes
Aslan, Hatice Esra; Beydemir, Şükrü (Elsevier Ireland LTD, 2017)The polyol pathway called as sorbitol way is a small part of glycose metabolism. The pathway is regarded as an important element in the pathogenesis of various diabetic complications in individuals with diabetes mellitus. ...