Kurum Yazarı "Benkli, Kadriye" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes
Varol, Mehmet; Koparal, Ayşe Tansu; Benkli, Kadriye; Bostancıoğlu, Rakibe Beklem (Bentham Science Publ LTD, 2018)Background: Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the long-term side effects. Objective: A ... -
Antibacterial and antifungal activities of some trimethoprim salts
Tunalı, Yağmur; Karaca, Hülya; İşcan, Gökalp; Demirci, Fatih; Benkli, Kadriye (Birkhauser Boston Inc, 2012)In this study, the antimicrobial activities of Trimethoprim (1), Trimethoprim + Maleic acid (2), Trimethoprim + Oxalic acid dihydrate (3), and Trimethoprim + trans-1,2-Cyclohexanedicarboxylic acid (4) were investigated for ... -
Apoptotic effects of dipyrido [3,2-a:2 ',3 '-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats
Tekin, Neslihan; Üstüner, Mehmet C.; Akyüz, Fahrettin; Özbayer, Cansu S.; Aydın, Özlem; Benkli, Kadriye; Özden, Hilmi (Springer, 2014)We evaluated the effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex ([Au(dppz)Cl-2]Cl) on apoptosis during chemically induced hepatocellular carcinoma. 48 male Spraque-Dawley rats were divided into six ... -
Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates
Bayulken, Devrim Güzel; Bostancıoğlu, Rakibe Beklem; Koparal, Ayşe Tansu; Tüylü, Berrin; Dağ, Aydan; Benkli, Kadriye (Springer, 2018)Trimethoprim, a commonly used antibacterial agent, is widely applied in the treatment of variety of infections in human. A few studies have demonstrated an extensive exposure of man to antibiotics, but there is still a ... -
Biological activities of Cu(II) and Hg(II) complexes of a heptadentate Schiff base ligand
Ergene, Emel; Sivas, Hülya; Benkli, Kadriye (Tubitak Scientific & Technical Research Council Turkey, 2010)Two metal complexes were synthesized as [Hg(L)](ClO4)(2) and [Cu(L)](ClO4), by the template reaction between 2,6-bis(2-aminothiophenoxymethyl)pyridine and 2,2'-bipyridine-6,6'-dicarboxaldehyde in the presence of Hg(II) and ... -
Cytotoxic and genotoxic effects of [Ru(phi)(3)](2+) evaluated by Ames/Salmonella and MTT methods
Benkli, Kadriye; Tunalı, Yağmur; Cantürk, Zerrin; Artagan, öge; Alanyali, Filiz (Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)In this work, we synthesized and evaluated the cytotoxic effect of [Ru(phi)(3)](2+), on rat C6 glioma cell line. Cell viability was determined by assay with 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide ... -
Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents
Varol, Mehmet; Benkli, Kadriye; Koparal, Ayşe Tansu; Bostancıoğlu, Rakibe Beklem (Taylor & Francis LTD, 2019)Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. ... -
The effects of some phenanthroline ruthenium (II) complexes on A549 cell proliferation [Bazi{dotless} fenantrolin rutenyum (II) komplekslerinin a549 hücre çogalmasi{dotless} üzerine etkileri]
In recent years, ruthenium (II) complexes have increasingly attracted the interest of researchers because of their high antitumor activities that are usually related to DNA binding. Here, we synthesized two ruthenium (II) ... -
Gold(III) compounds-mediated inhibition of lung cancer cell proliferation
Bostancıoğlu, R. Beklem; Kaya, Murat; Koparal, Ayşe Tansu; Benkli, Kadriye (Lippincott Williams & Wilkins, 2016)Research on chemotherapeutics for lung cancer is crucial for designing a new therapeutic strategy against malignant lung tumors. Although radiotherapy and chemotherapy, which are not selective for cancer cells and exert ... -
The in vitro assessment of dipyridophenazine complexes in H-ras oncogene transformed rat embryo fibroblast 5RP7 cell line
Kaplan, Ayşe; Benkli, Kadriye; Koparal, Ayşe Tansu (Springer, 2018)Purpose The aim of this study is to detect apoptotic and cytotoxic/antiproliferative effects of a ligand substance and its metal derivatives. The substances were investigated by using an h-ras oncogene transformed rat ... -
Inhibition of C6 Glioma Cell Proliferation by Au(III) and Pt(II) Complexes of 1,10-Phenanthroline-5,6-dione
Dikmen, Miriş; Benkli, Kadriye; Öztürk, Yusuf (Asian Journal Of Chemistry, 2011)In this study, we studied the antiproliferative effecs of Au(III) and Pt(II) metal complexes of 1,10-phenanthroline-5,6-dione and cisplatin on rat glioma C6 cells. The antiproliferative effects were evaluated by MTT ... -
Investigation of the pharmacological profiles of dinuclear metal complexes as novel, potent and selective cytotoxic agents against leas-transformed cells
Bostancıoğlu, R. Beklem; Koparal, Ayşe Tansu; Benkli, Kadriye (Elsevier Science BV, 2014)Around the world scientists try to design successful cures against still incurable diseases, especially cancers. New targets for prevention and new agents for therapy need to be identified. We synthesized novel metal ... -
Modification of intracellular free calcium in cultured F2408 embryo fibroblasts by 3-sub substituted-2-thiohydantoin derivatives
Seller, Zerrin; Benkli, Kadriye; Akalın, G; Kaplancıklı, Zafer Asım (Wiley, 2004)3-substituted-2-thiohydantoin derivatives were synthesized and their Structures elucidated by IR, H-1-NMR spectroscopy and elemental analysis. The cytotoxicity of the 2-thiohydantoin derivatives to rat embryo fibroblasts ... -
Production of ?-terpineol from ?-pinene
?-Terpineol is a monoterpene alcohol used as a fragrance material in perfumery industry and for the production of some volatile compounds. Several techniques have been described in the literature for its synthesis. These ... -
Some 1-substituted 3-aryl-1,4-dihydro-1,2,4-triazino[4,3-a]- benzimidazoles and their vasodilatory activities
Demirayak, Şeref; Benkli, Kadriye; Karaburun, Ahmet Çağrı (Societa Chimica Italiana, 1997)In this study, some 1-substituted 3-aryl-1,4-dihydro-1,2,4- triazino[4,3-a]benzimidazole derivatives were synthesized, their structures were elucidated, and their vasodilatory activities were examined. It was found that ... -
Studies on the cytotoxic, apoptotic and antitumoral effects of Au(III) and Pt(II) complexes of 1, 10-phenanthroline on V79 379A and A549 cell lines
Bostancıoğlu, R. Beklem; Işık, Kenan; Genç, Hatice; Benkli, Kadriye; Koparal, Ayşe Tansu (Informa Healthcare, 2012)In the present study, Au(III) and Pt(II) complexes of 1, 10-phenanthroline (phen) were synthesized and used as the test compounds. The structure elucidation of the synthesized compounds was performed by IR, H-1-NMR and ... -
Studies on the synthesis of some new antipyrine derivatives
Some new 4-(4, 5-diarylimidazole-2-yl) antipyrine, 4-(5-substituted benzimidazole-2-yl) antipyrine and 4-(phenantroimidazole-2-yl) antipyrine derivatives were synthesised. The structure elucidations of the compounds were ... -
Synthesis and antifungal activities of some aryl (3-methyl-benzofuran-2-yl) ketoximes
Benkli, Kadriye; Gündoğdu-Karaburun, N; Karaburun, Ahmet Çağrı; Uçucu, Ümit; Demirayak, Şeref; Kiraz, N (Pharmaceutical Society Korea, 2003)In this study, some aryl (3-methyl-benzofuran-2-yl) ketoximes and their. ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, H-1-NMR, MASS spectroscopy and elemental analyses. ... -
Synthesis and antifungal activities of some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes
Gündoğdu-Karaburun, Nalan; Benkli, Kadriye; Tunalı, Yağmur; Uçucu, Ümit; Demirayak, Şeref (Elsevier France-Editions Scientifiques Medicales Elsevier, 2006)In this study, some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketones, aryl (3-methyl-benzofuran-2-yl) ketoximes and aryl [3(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketoximes were synthesised ... -
Synthesis and antifungal activities of some aryl(benzofuran-2-yl)ketoximes
Demirayak, Şeref; Uçucu, Ümit; Benkli, Kadriye; Gündoğdu-Karaburun, Nalan; Karaburun, Ahmet Çağrı; Akar, D; Kiraz, N (Elsevier Science Sa, 2002)In this study, some aryl(benzofuran-2-yl)ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, H-1 NMR and mass spectroscopic data and elemental analyses ...