Kurum Yazarı "Dikmen, Miriş" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms
Alyu, Feyza; Dikmen, Miriş (Cambridge University Press, 2017)Objective Epilepsy is a chronic neurological disease characterised with seizures. The aetiology of the most generalised epilepsies cannot be explicitly determined and the seizures are pronounced to be genetically determined ... -
Inhibition of C6 Glioma Cell Proliferation by Au(III) and Pt(II) Complexes of 1,10-Phenanthroline-5,6-dione
Dikmen, Miriş; Benkli, Kadriye; Öztürk, Yusuf (Asian Journal Of Chemistry, 2011)In this study, we studied the antiproliferative effecs of Au(III) and Pt(II) metal complexes of 1,10-phenanthroline-5,6-dione and cisplatin on rat glioma C6 cells. The antiproliferative effects were evaluated by MTT ... -
Inhibitory effects of secondary metabolites of halotolerant aspergillus terreus on angiogenesis
Dikmen, Miriş; Cantürk, Zerrin; Engür, Selin; Kaya, Tilki, E. (Scientific Publishers of India, 2017)Angiogenesis inhibitors have been currently developed which offer the hope of new treatment options such as diabetic retinopathy, psoriasis, rheumatoid arthritis and cancer. Fungi have been known (as) a wide useful source ... -
Investigation of association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism frequency and plasma PAI-1 enzyme activity in patients with acute stroke
Küçükarabacı, Banu; Güneş, Hasan Veysi; Özdemir, Gazi; Coşan, Didem; Ozbabalik, Demet; Dikmen, Miriş; Değirmenci, İrfan (Mary Ann Liebert, Inc, 2008)Aim: This study was carried out to determine if there is any association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism and plasma PAI-1 enzyme activity in acute stroke patients. Methods: ... -
Investigation of the Apoptotic Effect of Curcumin in Human Leukemia HL-60 Cells by Using Flow Cytometry
Dikmen, Miriş; Cantürk, Zerrin; Öztürk, Yusuf; Tunalı, Yağmur (Mary Ann Liebert, Inc, 2010)Curcumin (diferuloylmethane), the major yellow pigment isolated from the turmeric (Curcuma longa), has received much attention due to several biological properties. Curcumin exhibits a variety of pharmacological effects ... -
Is there any role of G-protein estrogen receptor gene (GPR30) polymorphism in development of schizophrenia?
Özen, Murat Eren; Dikmen, Miriş; Tap, Duygu; Özler, Sinan; Yılmaz, Mehmet Bertan; Urhan Küçük, Meral (Cumhuriyet University Tip Fak Psikiyatri Anabilim Dali, 2019)Objectives: Schizophrenia is a complex neuropsychiatric disorder that affects approximately 1% of the population. Estrogens may play an important role in the etiology and treatment of this disorder. They mediate effect by ... -
Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae)
Mustafa, Ahmed M.; Maggi, Filippo; Papa, Fabrizio; Kaya, Elif; Dikmen, Miriş; Öztürk, Yusuf (Elsevier Sci LTD, 2016)In the search for neuroactive compounds that mimic the nerve growth factor (NGF) activity for the protection against neurodegenerative diseases, the potential medicinal values of foods and plants attracts intense interest. ... -
mTOR Inhibitors in the Treatment of Cancer
Özcan, Özge; Dikmen, Miriş (Marmara University, Fac Pharmacy, 2015)The mammalian target of rapamycin (mTOR) is a highly conserved in evolution serine/threonine kinase belonging to the phosphatidylinositol kinase related protein kinases family. mTOR plays a central role in regulation of a ... -
Neuritogenic Activity of Epigallocatechin Gallate and Curcumin Combination on Rat Adrenal Pheochromocytoma Cells
Dikmen, Miriş; Kaya-Tilki, Elif; Engür, Selin; Öztürk, Yusuf (Parlar Scientific Publications (PSP), 2017)Plant phytochemicals are important neuroprotective agents which mainly act as antioxidants by scavenging stress -induced free radicals in the brain. Phytochemicals from medicinal plants including epigallocatechin gallate ... -
New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors
Karaman, Nurcan; Sıcak, Yusuf; Taşkın-Tok, Tuğba; Öztürk, Mehmet; Karakuçuk-İyidoğan, Ayşegül; Dikmen, Miriş; Oruç-Emre, Emine Elçin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Hydrazones and the piperidine ring containing compounds were considered as beneficial substrates in drug design. Therefore, this study was aimed at the synthesis of new benzoyl hydrazones derived from ethyl 4-oxopiperidi ... -
Plasminogen Activator Inhibitor Type-1 Gene 4G/5G Polymorphism Is Associated with Hypertensive Patients in the Turkish Population
Güneş, Hasan Veysi; Coşan, Didem Turgut; Ata, Necmi; Birdane, Alparslan; Üstüner, Mehmet Cengiz; Dikmen, Miriş; Değirmenci, İrfan (Mary Ann Liebert Inc, 2010)This study has been performed on hypertensive patients in the Turkish population to determine the frequency of 4G/5G polymorphism genotypes of plasminogen activator inhibitor type-1 gene and with the aim of examining the ... -
Synthesis and Anticancer Activity of New Hydrazide-hydrazoncs and Their Pd(II) Complexes
Koçyiğit-Kaymakçıoğlu, Bedia; Yazıcı, Senem Sinem; Tok, Fatih; Dikmen, Miriş; EnGür, Selin; Oruç-Emre, Emine Elçin; Iyidoğan, Ayşegül (Bentham Science Publ LTD, 2019)Background: Hydrazones, one of the important classes of organic molecules, are pharmaceutical agents comprising -CO-NH-N=CH- group in the structure therefore and exhibiting significant biological activity. Methods: ... -
Synthesis and antiproliferative activity evaluation of new thiazole-benzimidazole derivatives using real-time cell analysis (RTCA DP)
Özkay, Yusuf; Yurttaş, Leyla; Dikmen, Miriş; EnGür, Selin (Springer Birkhauser, 2016)A series of new 2-[(5-substituted-1H-benzimidazol-2-yl)thio]-N-[4-[2-phenylthiazol-4-yl]phenyl]acetamide derivatives (4a-p) were synthesized according to the reported literature, and anticancer activity of the compounds ... -
Synthesis of some hydrazone derivatives bearing purine moiety as anticancer agents [Antikanser ajanlar olarak pürin parçasi{dotless} taşi{dotless}yan bazi{dotless} hidrazon türevlerinin sentezi]
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Dikmen, Miriş (Turkish Pharmacists Association, 2014)In the present study, some hydrazone derivatives were synthesized via the reaction of 6-hydrazino-9-(ß-D-ribofuranosyl)-9H-purine with various benzaldehydes. The structures of the compounds were elucidated by spectroscopic ...