Kurum Yazarı "Can, Özgür Devrim" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Effects of Insulin and St. John's Wort Treatments on Anxiety, Locomotory Activity, Depression, and Active Learning Parameters of Streptozotocin-Diabetic Rats
Can, Özgür Devrim; Öztürk, Yusuf; Özkay, Ümide Demir (Georg Thieme Verlag Kg, 2011)The aim of this work was to investigate the effects of St. John's Wort (SJW) extract treatment on behavioral changes arising in streptozotocin (STZ)-diabetic rats. Plus-maze, activity cage, modified forced swimming, and ... -
Effects of long-term agomelatine treatment on the cognitive performance and hippocampal plasticity of adult rats
Özkay, Ümide Demir; Soztutar, Erdem; Can, Özgür Devrim; Ucel, Umut İrfan; Öztürk, Yusuf; Ulupınar, Emel (Lippincott Williams & Wilkins, 2015)Agomelatine is an antidepressant with a distinct pharmacological mechanism of action as an MT1 and MT2 receptor agonist and as a 5-HT2C receptor antagonist. We evaluated the chronic effects of agomelatine administration ... -
Effects of Some 1,3,5-Trisubstitued-2-pyrazoline Derivatives on Depression and Anxiety Parameters of Mice
Can, Özgür Devrim; Özkay, Ümide Demir; Kaplancıklı, Zafer Asım; Öztürk, Yusuf (Pharmaceutical Soc Korea, 2009)The aim of the present study was examining the effects of some 1,3,5-trisubstituted-2-pyrazoline derivatives on depression, anxiety and spontaneous locomotor activity parameters of mice. None of the compounds was effective ... -
Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats
Can, Özgür Devrim; Öztürk, Yusuf; Öztürk, Nilgün; Sagratini, Gianni; Ricciutelli, Massimo; Vittori, Sauro; Maggi, Filippo (Elsevier Science BV, 2011)This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week ... -
An evaluation of the bottom ashes from healthcare waste in a laboratory scale incinerator: Microbiology, mutagenicity and toxicity
Malkoç, Semra; Banar, Müfide; Tüylü, Berrin; Korkmaz, S; Can, Özgür Devrim (Parlar Scientific Publications (PSP), 2006)In this study, experiments of healthcare waste incineration at 500, 600, 700, 800 and 900 degrees C in a lab-scale incinerator were carried out, performing different total bacterial counts for the microorganisms in bottom ... -
Huperzine A: A nootropic agent in the shade [Huperzin A: Gölgede Kalmış bir Nootropik Ajan]
Turan, Yücel, N.; Can, Özgür Devrim (Society of Pharmaceutical Sciences of Ankara (FABAD), 2019)Huperzine A is a sesquiterpene alkaloid found in the chemical composition of the medical plant Huperzia serrata. Huperzine A has attracted the attention of neuroscientists after the discovery of its strong and selective ... -
Investigating the Antidepressant-like Effects of some Benzimidazolepiperidine Derivatives by In-Vivo Experimental Methods
Turan, Nazlı; Özkay, Ümide Demir; Can, Nafiz Öncü; Can, Özgür Devrim (Bentham Science Publ LTD, 2019)Background: Benzimidazole and piperidine rings are important pharmacophore groups for drug design studies. Objective: In this study, we aimed to investigate the antidepressant-like activity of some 2-(4- substituted-phen ... -
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir; Sağlık, Begüm Nurpelin; Levent, Serkan; Ilgın, Sinem; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[dlimidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, ... -
Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney
Şahin, Erhan; Bektur, Ezgi; Dönmez, Dilek Burukoğlu; Baycu, Cengiz; Can, Özgür Devrim; Şahintürk, Varol (Elsevier GMBH, 2019)Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus. Materials and methods: The rats were randomly ... -
A natural antidepressant: Hypericum perforatum L.: Review [Dogal Bir Antidepressan: Hypericum Perforatum L]
Can, Özgür Devrim; Öztürk, Yusuf; Demir, Özkay, Ü. (Turkiye Klinikleri, 2009)Hypericum perforatum L. is a plant, which has heen traditionally used for various ethnopharmacological purposes, including treatment of mental disorders. Reported pharmacological activities of the plant extract on central ... -
New antidepressant drug candidate: Hypericum montbretti extract
Can, Özgür Devrim; İsmail, İsmail Bilal; Öztürk, Yusuf; Öztürk, Nilgün; Potoğlu-Erkara, Ismuhan; Sagratini, Gianni; Maggi, Filippo (Taylor & Francis LTD, 2011)This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic ... -
New pyrazoline derivatives and their antidepressant activity
Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Altıntop, Mehlika Dilek; Can, Özgür Devrim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental ... -
Opioid system mediated anti-nociceptive effect of agomelatine in mice
Kasap, Merve; Can, Özgür Devrim (Pergamon-Elsevier Science LTD, 2016)Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these ... -
The other face of diabetes mellitus: Psychiatric and neurodegenerative complications: Review [Diabetes mellitus'un diger yüzü: Psikiyatrik ve nörodejeneratif komplikasyonlar]
Can, Özgür Devrim; Öztürk, Yusuf (Turkiye Klinikleri, 2009)Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia, which is caused by failure in insulin secretion and/or action and it triggers various acute and chronic complications in patients. The ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice
Can, Özgür Devrim; Özkay, Ümide Demir; Kıyan, Hülya Tuba; Demirci, Betül (Elsevier GMBH, Urban & Fischer Verlag, 2012)In this study, the effect of Matricaria recutita L essential oil (MEO) on the central nervous system (CNS) of mice was investigated using some behavioral methods. Chemical profiling both by GC and GC-MS analyses of the ... -
Role of St. John’s wort (Hypericum perforatum L.) in the management of diabetes and neurological disorders
Öztürk, K, Y.; Can, Özgür Devrim; Demir-Özkay, Ümide (Apple Academic Press, 2018)2St. John’s Wort (Hypericum perforatum L.) is a widely utilized antidepressant plant, which has been used as both therapeutic drug and over-the-counter (OTC) product in all around the world. There are many ethnomedical, ... -
Synthesis and analgesic activity of some acetamide derivatives
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Turan, Gülhan; Özdemir, Ahmet; Can, Özgür Devrim (Informa Healthcare, 2012)In the present study, some acetamide derivatives were synthesized and their potential analgesic activities were investigated. N-(benzothiazol-2-yl)-2-[(1-substituted-1H-tetrazol-5-yl) thio] acetamide derivatives were ... -
Synthesis and analgesic effects of 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives
Özkay, Ümide Demir; Özkay, Yusuf; Can, Özgür Devrim (Springer Birkhauser, 2011)This present study was undertaken to synthesize and investigate possible analgesic activities of some 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives that were designed by combining an analgesic ... -
Synthesis and anti-nociceptive, anti-inflammatory activities of new aroyl propionic acid derivatives including N-acylhydrazone motif
Turan, Gülhan; Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Can, Özgür Devrim; Özkay, Ümide Demir (Springer Birkhauser, 2015)In the present study, new 4-[4-[2-(2-(4-substituted benzylidene)hydrazinyl)-2-oxoethoxy]phenyl]-4-oxobutanoic acid derivatives were synthesized, and their anti-nociceptive and anti-inflammatory activities were investigated. ...