Kurum Yazarı "Ak, Dilek" Scopus İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Development of a CD-MEKC method for investigating the metabolism of tamoxifen by flavin-containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA
Yeniceli, Duygu; Deng, Xiaolan; Adams, Erwin; Ak, Dilek; Van Schepdael, Ann (Wiley-Blackwell, 2013)A selective and low-cost CD-MEKC method under acidic conditions was developed for investigating the N-oxygenation of tamoxifen (TAM) by flavin-containing monooxygenases (FMOs). The inhibitory effects of methimazole (MMI), ... -
A differential pulse voltammetric determination of nisoldipine using glassy carbon electrode in pharmaceutical preparations
Ak, Dilek; gökoren, N; Tunçel, Muzaffer (Marcel Dekker Inc, 1998)A differential pulse voltammetric method is described for the determination of nisoldipine based on the oxidation of the dihydropyridine group on the surface of a rotating glassy carbon disk electrode. The voltammetric ... -
Effect of nitric oxide inhibition on rat liver ischemia reperfusion injury
Özakyol, A. H.; Tunçel, N.; Sarıçam, T.; Uzuner, K.; Ak, Dilek; Gürer, Firdevs (2000)Objective: To determine the role of nitric oxide (NO) in rat liver ischemia reperfusion we examined the effects of competitive NO synthesis inhibitor L-nitro-arginine-methyl-ester (L-NAME) and NO precursor L-arginin. ... -
The Effects of Vasoactive Intestinal Peptide on Dura Mater Nitric Oxide Levels and Vessel-Contraction Responses in Sympathectomized Rats
Töre, Fatma; Korkmaz, Orhan Tansel; Ak, Dilek; Tuncel, Neşe (Humana Press Inc, 2010)Nitric oxide (NO) and neurogenic inflammation in dura mater due to nociceptor activation has been implicated for pathophysiology of primary headache disorders. Development of migraine has also been observed in patients ... -
The electroanalytical behaviour of ancitabine
Ak, Dilek; Tuncel, M. (1994)The direct current polarographic behaviour of ancitabine based on the reduction of the molecule is described and the optimum polarographic conditions for its determination are presented in this study. The experiments were ... -
Establishment and characterization of new murine breast cancer cell lines
The establishment of two new breast cancer cell lines, MXT+ and MXT-, derived from the murine breast cancer models MXT-M-3,2 MC (hormone-sensitive) and MXT-M-3,2 (ovex) MC (hormone-insensitive), is described. Characterization ... -
Flow injection analysis of mitomycin-C in flacons
Dal, Arın Gül; Ak, Dilek; Tunçel, Muzaffer (2005)A precise and accurate flow injection analysis (FIA) method for the determination of mitomycin-C (MMC) in pharmaceutical flacons is described. Britton-Robinson (BR) buffer at pH 7.0 was used as a carrier solvent at a ... -
Flow-through spectrophotometric determination of omeprazole in pharmaceutical preparations containing enteric coated pellets
Tunçel, Muzaffer; Ak, Dilek (Govi-Verlag Pharmazeutischer Verlag GMBH, 1997)… -
Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models
Ak, Dilek; Kumar, Vijaya B.; Ryerse, Jan S.; Farr, Susan A.; Verma, Şulekha; Nonaka, Naoko; Banks, William A. (Sage Publications Inc, 2009)By isolating for the first time ever a peptide transporter from the blood-brain barrier (BBB) and developing an antisense that selectively targets the brain-to-blood efflux component, we were able to deliver a therapeutic ... -
An LC Method for the Determination of Bupropion and Its Main Metabolite, Hydroxybupropion in Human Plasma
Yeniceli, Duygu; Ak, Dilek (Springer Heidelberg, 2009)A new LC method has been developed and validated for the direct determination of bupropion and its main metabolite, hydroxybupropion in human plasma. Plasma samples were analyzed after a simple, one step protein precipitation ... -
Modified method for the determination of capillary electrophoresis nitric oxide-correlated nitrate in tissue homogenates
Tunçel, Muzaffer; Ak, Dilek; Erkasap, Nilüfer (2001)A modified capillary electrophoretic method for the determination of nitric oxide correlated nitrate in several tissue homogenates is described in this study. The method was developed using a running buffer consisting of ... -
Passage of vasoactive intestinal peptide across the blood-brain barrier
Ak, Dilek; Banks, WA; Tuncel, N; Tunçel, Muzaffer (Elsevier Science Inc, 2003)We investigated the ability of vasoactive intestinal peptide (VIP) to cross the blood-brain barrier (BBB), the interface between the peripheral circulation and central nervous system (CNS). VIP labeled with I-131 (I-VIP) ... -
Passage of VIP/PACAP/secretin family across the blood-brain barrier: Therapeutic effects
In recent years, VIP/PACAP/secretin family has special interest. Family members are vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), secretin, glucagon, glucagon like peptide-1 ... -
A polarographic study on dipyridamole and its determination in commercial tablets
Tunçel, Muzaffer; Ak, Dilek; Atkoşar, Zeki. (1991)The direct current polarographic behaviour of dipyridamole, a coronary vasodilator, in the supporting electrolyte consisting of 0.2 M KC1, 20 % (v/v) ethanol and buffer solutions is described in this study. Morphologically ... -
The protective effect of vasoactive intestinal peptide (VIP) on stress-induced gastric ulceration in rats
Tunçel, N.; Erkasap, N.; Şahintürk, V.; Ak, Dilek; Tunçel, Muzaffer (New York Academy of Sciences, 1998)The pathogenesis of cold restraint stress ulcer involves various factors and is not completely understood. Mast cell degranulation, increased gastric muscular contractility, diminished mucosal blood flow, release of several ... -
Retention Behaviour of Bupropion Hydrochloride in Reversed Phase Ion Pair LC and Validated Analysis of the Drug in Pharmaceuticals
Yeniceli, Duygu; Ak, Dilek (Springer Heidelberg, 2010)The chromatographic behaviour of bupropion hydrochloride, a basic drug of pK (a) 7.9, has been investigated under reversed-phase ion-pairing conditions and the results were used to develop a method for analysis of bupropion ... -
A simple and sensitive LC-ESI-MS (ion trap) method for the determination of bupropion and its major metabolite, hydroxybupropion in rat plasma and brain microdialysates
Yeniceli, Duygu; Şener, Erol; Korkmaz, Orhan Tansel; Ak, Dilek; Tuncel, Neşe (Elsevier Science BV, 2011)A specific and highly sensitive liquid chromatography-electrospray mass spectrometry (LC-ESI-MS) method for the direct determination of bupropion (BUP) and its main metabolite hydroxybupropion (HBUP) in rat plasma and brain ... -
A Simple and Specific Hplc Method for the Determination of Atomoxetine in Pharmaceuticals and Human Plasma
Ak, Dilek; Yeniceli, Duygu (Taylor & Francis Inc, 2010)A liquid chromatographic method has been described for the determination of atomoxetine in pharmaceuticals and human plasma. Plasma samples were analyzed after a simple, one step protein precipitation with methanol, and ... -
Simultaneous Determination of Substance P and CGRP in Rat Brainstem Tissue Using LC-ESI-MS/MS Method
Alasag, Neva; Şener, Erol; Ak, Dilek (Bentham Science Publ LTD, 2018)Background: Substance P and CGRP are neuropeptides that belong to the thachykinin and calcitonin family, respectively. They play an important role in neuropathic pain development and regulation. Methods: In this study, ... -
A Study on the Polarographic-Behavior and Determination of Tizanidine
Tunçel, Muzaffer; Ak, Dilek (Marcel Dekker Inc, 1992)The direct current polarographic behaviour of tizanidine based on the reduction of the molecule on the surface of DME is described and the optimum polarographic conditions for the determination are presented in this study. ...