Ara
Toplam kayıt 137, listelenen: 121-130
Comparison of antiproliferative and apoptotic effects of a novel proteasome inhibitor MLN2238 with bortezomib on K562 chronic myeloid leukemia cells
(Taylor & Francis LTD, 2016)
Inhibition of the proteasome has emerged as a clinically effective anticancer therapeutic approach in recent years. Bortezomib (Velcade (R)) showed extremely high potency against a wide range of cancer cell lines. Ixazomib ...
Extract of Hypericum perforatum blocks nicotine-induced locomotor activity in mice
(2006)
In the present study, the effects of Hypericum perforatum on nicotine-induced locomotor activity have been investigated in mice. Adult male Swiss-Webster mice were subjects. Nicotine (0.5, 1 and 2 mg/kg) and saline were ...
Decreased gastro-intestinal responses to salbutamol and serotonin in streptozotocin-induced diabetes: Improving effect of insulin in vivo and in vitro
(1988)
1. 1. Decreased gastro-intestinal responses to salbutamol (sal) and serotonin (5-HT) in experimental diabetes have been postulated. The present study was designed to investigate whether in vivo and in vitro insulin treatments ...
Effect of Short and Long-Term Streptozotocin Diabetes on Smooth-Muscle Calmodulin Levels in the Rat
(Churchill Livingstone, 1994)
Diabetes mellitus is a metabolic disease associated with certain complications which have also been demonstrated in the experimental models of this disease. Altered responses to several agonists have been reported in various ...
Effect of Insulin on the Decreased Beta-Adrenergic Responses of Duodenum and Atrium Isolated From Streptozotocin Diabetic Rats
(Pergamon-Elsevier Science LTD, 1993)
1. Decreased beta-adrenergic responses have been reported in both gastro-intestinal tract and atrium of experimentally-induced diabetic rats. The present study was undertaken to investigate in vitro effects of insulin on ...
Investigation of Origanum onites, Sideritis congesta and Satureja cuneifolia essential oils for analgesic activity
(John Wiley & Sons LTD, 1996)
Essential oils, obtained by Clevenger distillation, of Sideritis congesta P. H. Davis et Hub.Mor., Satureja cuneifolia Ten. and Origanum onites L. collected from two different localities were investigated for their analgesic ...
The involvement of endogenous opioid mechanisms in the antinociceptive effects induced by antidepressant drugs, desipramine and trimipramine
(Pergamon-Elsevier Science LTD, 2006)
The present study was designed to investigate the involvement of endogenous opioid systems in the antinociception induced by the antidepressant drugs, desipramine and trimipramine. For this purpose, the antinociceptive ...
The Effects of Glyburide and Insulin on the Cardiac-Performance in Rats With Non-Insulin-Dependent Diabetes-Mellitus
(Pergamon-Elsevier Science LTD, 1993)
1. The effects Of glyburide were studied on the myocardial contractile force and heart rate in the atria isolated from non-diabetic and non-insulin-dependent diabetic rats (diabetic). 2. In order to examine the myocardial ...
An in vivo database model for pharmacological and physiological dosage for experimental animals
(Pergamon-Elsevier Science LTD, 2009)
We developed a database compiling in vivo doses of compounds for various activities in certain animal species. The related database covers almost 100 years of experiments. The conceptual scheme of the database was created ...
Pharmacological and toxicological effects of gas plant (Dictamnus Albus L.)
(2005)
Bu çalışmanın amacı Akgiritotu'nun farmakolojik ve toksikolojik etkilerini araştırmaktır. Yaprak ve meyvalarmdan hazırlanan sulu ekstreler kobay derisi üzerinde 2,4-dinitrobenzen ile karşılaştırmalı olarak test edilmiştir. ...