Kurum Yazarı "Can, Özgür Devrim" İçin Listeleme
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1,3,5-triaril-4,5-dihidro-1h-pirazol türevi bazı bileşiklerin benzodiazepin reseptörleri aracılıklı anksiyolitik-benzeri etkileri
Can, Özgür Devrim; Turan, Nazlı; Alyu, Feyza (2016)Amaç: Pirazol, üç karbon atomundan ve yan yana iki azot atomundan oluşan beş üyeli heterosiklik bir halka sistemidir. Literatürde pirazol çekirdeği taşıyan kimyasal bileşiklerin santral sinir sistemi üzerinde önemli bir ... -
Acetylcholinesterase Inhibitory Effects of Some Benzothiazole-Piperazine Derivatives
Demir Özkay, Ümide; Can, Özgür Devrim; Özkay, Yusuf (Elsevier Science BV, 2011)… -
Analgesic activity of Hawthorn seed extract
Can, Özgür Devrim; Özkay, Ümide Demir; Nilgün, Öztürk; Öztürk, Yusuf (Acta Pharmacologica Sinica, 2006)… -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid: Evidence for the importance of the 2-(o-substituted phenyl) group
Aydın, Süleyman; Arslan, Rana; Can, Özgür Devrim (2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1H-benzimidazole 5-carboxylic acid: evidence for the importance of the 2-(o-substituted phenyl) group
Aydın, Süleyman; Arslan, Rana; Can, Özgür Devrim (Govi-Verlag GMBH, 2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of monoaminergic mechanisms
Can, Özgür Devrim; Özkay, Ümide Demir; Ucel, Umut İrfan (Elsevier Science BV, 2013)The present study was designed to investigate the putative effect of vitexin, a flavone C-glucoside present in some drugs, medicinal plants and nutraceuticals, on the central nervous system. Vitexin (10-30 mg/kg) did not ... -
Anti-nociceptive effect of vitexin mediated by the opioid system in mice
Özkay, Ümide Demir; Can, Özgür Devrim (Pergamon-Elsevier Science LTD, 2013)In the present study, we determined the potential anti-nociceptive activity of vitexin, a C-glycosylated flavone, by conducting some acute nociceptive tests in mice. Centrally mediated anti-nociceptive effect was evaluated ... -
Anticholinesterase activity screening of some novel dithiocarbamate derivatives including piperidine and piperazine moieties
Levent, Serkan; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Can, Özgür Devrim; Özkay, Ümide Demir; Uçucu, Ümit (Taylor & Francis LTD, 2017)The present study was undertaken to synthesize some novel lipophilic piperazine and piperidinedithiocarbamates and investigate their inhibitory potencies against cholinesterase enzymes. In the synthetic studies, 44 new ... -
Antidepressant-like effect of gallic acid in mice: Dual involvement of serotonergic and catecholaminergic systems
Can, Özgür Devrim; Turan, Nazlı; Özkay, Ümide Demir; Öztürk, Yusuf (Pergamon-Elsevier Science LTD, 2017)Aims: This study was planned to examine the antidepressant potency of gallic acid (30 and 60 mg/kg), a phenolic acid widely distributed in nature, together with its possible underlying monoaminergic mechanisms. Main methods: ... -
Antihyperalgesic Activity of Atomoxetine on Diabetes-Induced Neuropathic Pain: Contribution of Noradrenergic and Dopaminergic Systems
Barbaros, Mustafa Burak; Can, Özgür Devrim; Ucel, Umut İrfan; Yücel, Nazlı Turan; Özkay, Ümide Demir (MDPI, 2018)Atomoxetine is a selective noradrenaline reuptake inhibitor drug. Based on the knowledge that agents increasing monoamine levels in the central nervous system have therapeutic potential for neuropathic pain, it is planned ... -
Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: A study on mechanism of action
Ucel, Umut İrfan; Can, Özgür Devrim; Özkay, Ümide Demir; Öztürk, Yusuf (Elsevier Science BV, 2015)This study used various experimental pain methods to investigate the effects of subacute mianserin administration on diabetes-induced neuropathic pain in rats. The effect of mianserin on hyperalgesia occurring in connection ... -
Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways
Can, Özgür Devrim; Alyu, Feyza; Turan, Nazlı; Özdemir, Ahmet (Bentham Science Publ LTD, 2016)This study was planned to investigate possible antinociceptive activity of 1,5-diaryl-3-[4-(methylsulfonyl) phenyl]-4,5-dihydro-1H-pyrazole derivatives (2a-s), based on the analgesia-inducing potential of 4,5-dihydro-1H-pyrazole ... -
Antinociceptive activities of some triazole and pyrazoline moieties-bearing compounds
Özkay, Ümide Demir; Can, Özgür Devrim; Kaplancıklı, Zafer Asım (Springer Birkhauser, 2012)This study was designed to evaluate the potential antinociceptive activities of some triazole-pyrazoline derivatives. All of the test compounds (100 mg/kg) increased the reaction times of mice in hotplate and tail-clip ... -
Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion
Bektur, Ezgi; Şahin, Erhan; Ceyhan, Emre; Dönmez, Dilek Burukoğlu; Canbek, Mediha; Baycu, Cengiz; Can, Özgür Devrim (Taylor & Francis LTD, 2019)Objectives: Neuropathic pain reduces the life qualities of patients with Diabetes mellitus. Clinical guidelines recommend relief in diabetic neuropathic pain through the use of some antidepressants, anticonvulsants, opioids ... -
A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats
Özkay, Ümide Demir; Can, Özgür Devrim; Sağlık, Begüm Nurpelin; Turan, Nazlı (Polish Acad Sciences Inst Pharmacology, 2017)Background: Acetylcholinesterase (AChE) inhibitors are frequently prescribed to mitigate the cognitive decline in Alzheimer's disease. Thus, we investigated the possible efficacy of the AChE inhibitor 2-[(6-Nitro-2-benzothiazolyl) ... -
Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms
Yaşar, Şahin Nuri; Can, Özgür Devrim; Öztürk, Nilgün; Sagratini, Gianni; Ricciutelli, Massimo; Vittori, Sauro; Maggi, Filippo (Wiley, 2013)Pharmacological effects of hydroalcoholic extract prepared from Hypericum origanifolium Willd. (Guttiferae) on behavioral parameters and pain perceptions of mice were investigated in this study. Depression, anxiety, ... -
Central nervous system activity of 2-(Naphthalen-1-yl)-4, 5-dimethyl-(1H)-imidazole(NDI)
Özkay, Yusuf; Özkay, Ümide Demir; Can, Özgür Devrim; Öztürk, Yusuf; Işıkdağ, İlhan (Blackwell Publishing, 2006)… -
Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms
Ilgın, Sinem; Can, Özgür Devrim; Atlı Eklioğlu, Özlem; Ucel, Umut İrfan; Şener, Erol; Güven, İlkay (Taylor & Francis LTD, 2015)Ciprofloxacin (CPX) is a fluoroquinolone antibiotic used for treating respiratory, urinary tract, gastrointestinal and abdominal infections. There are only a limited number of studies related to neurological adverse effects ... -
Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines
Özkay, Ümide Demir; Can, Özgür Devrim; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Levent, Serkan; Özkay, Yusuf; Atlı Eklioğlu, Özlem (Pergamon-Elsevier Science LTD, 2016)In the current study, 14 new benzothiazole-piperazine compounds were designed to meet the structural requirements of acetylcholine esterase (AChE) inhibitors. The target compounds were synthesised in three steps. Structures ...