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Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies
Isik, Mesut; Beydemir, Sukru; Demir, Yeliz; Durgun, Mustafa; Turkes, Cuneyt; Nasir, Abdul; Akkus, Musa (Elsevier, 2020)Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as antimicrobial drugs for a long time. in the present study, we investigated in vitro inhibitory activities of benzenesulfonamide derivatives ... -
Calcium channel blockers: molecular docking and inhibition studies on carbonic anhydrase I and II isoenzymes
Turkes, Cuneyt; Demir, Yeliz; Beydemir, Sukru (Taylor & Francis Inc, 9999)Carbonic anhydrases (CAs) are potent dehydration of carbonic acid and catalyst of the reversible hydration of carbon dioxide. Here, CA I and CA II was purified from human erythrocytes using the simple chromatographic method ... -
In Vitro and in Silico Studies on the Toxic Effects of Antibacterial Drugs as Human Serum Paraoxonase 1 Inhibitor
Turkes, Cuneyt; Beydemir, Sukru; Kufrevioglu, Omer Irfan (Wiley-V C H Verlag Gmbh, 2019)The core purpose of the current study was to investigate the interactions of widely used broad-spectrum antibacterial drugs developed in response to the increasing rate of antibiotic-resistant various bacteria and to ... -
Molecular docking and investigation of 4-(benzylideneamino)- and 4-(benzylamino)-benzenesulfonamide derivatives as potent AChE inhibitors
Isik, Mesut; Demir, Yeliz; Durgun, Mustafa; Turkes, Cuneyt; Necip, Adem; Beydemir, Sukru (Springer International Publishing Ag, 2020)The discovery of acetylcholinesterase inhibitors is important for the treatment of Alzheimer's disease (AD), known as the most common type of dementia. Due to the side effects of commonly used acetylcholinesterase inhibitors, ... -
New Isoindole-1,3-dione Substituted Sulfonamides as Potent Inhibitors of Carbonic Anhydrase and Acetylcholinesterase: Design, Synthesis, and Biological Evaluation
Gundogdu, Saliha; Turkes, Cuneyt; Arslan, Mustafa; Demir, Yeliz; Beydemir, Sukru (Wiley-V C H Verlag Gmbh, 2019)Herein, a series of isoindole-1,3-dione substituted sulfonamide derivatives (3, 4a-k) were designed, synthesized, and biologically evaluated, as inhibitors of carbonic anhydrase (CA) and acetylcholinesterase (AChE). CA and ... -
Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors
Istrefi, Qendresa; Turkes, Cuneyt; Arslan, Mustafa; Demir, Yeliz; Nixha, Arleta R.; Beydemir, Sukru; Kufrevioglu, Omer, I (Wiley-V C H Verlag Gmbh, 2020)In this study, 15 novel compounds in a series of sulfonamide-based ketenes (7a-o) were synthesized and characterized using Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry. ... -
Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases
Durgun, Mustafa; Turkes, Cuneyt; Isik, Mesut; Demir, Yeliz; Sakli, Ali; Kuru, Ali; Supuran, Claudiu T. (Taylor & Francis Ltd, 2020)Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, C-13 NMR, H-1 NMR, LC-MS and ... -
Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3-diaryltriazene-substituted sulfathiazole derivatives
Isik, Mesut; Akocak, Suleyman; Lolak, Nabih; Taslimi, Parham; Turkes, Cuneyt; Gulcin, Ilhami; Beydemir, Sukru (Wiley-V C H Verlag Gmbh, 9999)In the present study, a series of eleven novel 1,3-diaryltriazene-substituted sulfathiazole moieties (ST1-11) was synthesized by the reaction of diazonium salt of sulfathiazole with substituted aromatic amines and their ... -
Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, ?-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs
Lolak, Nebih; Akocak, Suleyman; Turkes, Cuneyt; Taslimi, Parham; Isik, Mesut; Beydemir, Sukru; Durgun, Mustafa (Academic Press Inc Elsevier Science, 2020)…
