Yazar "Sever, Belgin" için listeleme
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Biological evaluation of a series of benzothiazole derivatives as mosquitocidal agents
Sever, Belgin; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Tabanca, Nurhayat; Estep, Alden S.; Becnel, James J.; Bloomquist, Jeffrey R. (Sciendo, 2019)Aedes aegypti is associated with the transmission of numerous human and animal diseases, such as yellow fever, dengue fever, chikungunya, and more recently Zika virus. Emerging insecticide resistance has created a need to ... -
A Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells
Çiftçi, Gülsen Akalın; Sever, Belgin; Altıntop, Mehlika Dilek (Turkish Pharmacists Assoc, 2019)Objectives: Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of new potent anticancer agents targeting Akt. Materials ... -
Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer
Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı; 0000-0003-4847-9711; 0000-0001-5098-8967; 0000-0003-0280-5550; 0000-0002-8159-663X; Sever, Belgin; Akalın Çiftçi, Gülşen; Özdemir, Ahmet; Altıntop, Mehlika Dilek (2020)Thiosemicarbazonesrepresent an important class of ligandsfortargeted therapyof many types of cancer including non-small celllung cancer. In order to identify potential antitumoragentsfor targeted therapy oflung cancer, new ... -
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
Sever, Belgin; Altıntop, Mehlika Dilek; Radwan, M. O.; Özdemir, Ahmet; Otsuka, Masami; Fujita, M.; Çiftçi, H. I. (Elsevier Masson SAS, 2019)Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. Based on ... -
Design, synthesis and in vitro COX inhibitory profiles of a new series of tetrazole-based hydrazones
Anadolu Üniversitesi, Eczacılık Fakültesi; Altıntop, Mehlika Dilek; Sever, Belgin; Temel, Halide Edip; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Anadolu Üniversitesi, 2022)Inhibition of cyclooxygenases (COXs), by selective and nonselective inhibitors, is a favorable approach for pharmacologic intervention in a variety of disorders such as cancer. For this purpose, a new class of tetrazole-hydrazone ... -
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet; Altıntop, Mehlika Dilek (Marmara University, 2019)Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ... -
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
Altıntop, Mehlika Dilek; Çiftçi, Halil İbrahim; Radwan, Mohamed O.; Sever, Belgin; Kaplancıklı, Zafer Asım; Ali, Taha F. S.; Özdemir, Ahmet (MDPI, 2018)In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous ... -
Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Özdemir, Ahmet (MDPI, 2018)In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1-10) were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma, and NIH/3T3 ... -
Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Tilki, Elif Kaya; Dikmen, Miriş (MDPI, 2018)Parkinson's disease (PD) is a chronic, progressive, and age-related neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons caused by the accumulation of free radicals and oxidative stress. ... -
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Turan, Gülhan; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the current work, new 1,3,4-oxadiazole derivatives were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines. Compounds ... -
Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Osmaniye, Derya; Sağlık, Begüm Nurpelin, Begüm N.; Özdemir, Ahmet (Wiley-V C H Verlag GMBH, 2018)In an effort to develop potent monoamine oxidase (MAO) inhibitors, new pyrrole derivatives were obtained via the selective reduction of the CC bonds of 1-(1-methyl-1H-pyrrol-2-yl)-3-[5-(aryl)furan-2-yl]prop-2-en-1-ones ... -
Eskişehir'de Eczane Teknisyenleri üzerine Bir Araştırma
Bu çalışmada, Eskişehir'deki eczacıların bakış açısından eczane teknisyenlerinin değerlendirilmesi üzerine bir araştırma gerçekleştirilmesi amaçlanmıştır. Metod: Bu çalışmanın eczacıları tesadüfî örnekleme yöntemi ile ... -
In silico Molecular Docking and ADME Studies of 1 3,4-Thiadiazole Derivatives in Relation to in vitro PON1 Activity
Sever, Belgin; Küçükoğlu, Kaan; Nadaroğlu, Hayrunnisa; Altıntop, Mehlika Dilek (Bentham Science Publ LTD, 2019)Background: Paraoxonase 1 (PON1) is a paraoxonase, arylesterase and lactonase associated with protection of lipoproteins and cell membranes against oxidative modification. Objective: Based on antioxidative properties of ... -
Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies
Sever, Belgin; Altıntop, Mehlika Dilek; Kuş, Gökhan; Özkurt, Mete; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)In the current work, new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives (1-8) were synthesized via the ring closure reaction of 2-bromoacetophenone derivatives with 4-amino-5-[(5-methoxy-2-methyl-1(4-chlorobenzoyl)- ... -
Investigation of the inhibitory effects of isoindoline-1,3-dion derivatives on hCA-I and hCA-II enzyme activities
Nadaroğlu, H.; Güngör, A. A.; Gündoğdu, Ö.; Kishali, N. H.; Sever, Belgin; Altıntop, Mehlika Dilek (Elsevier B.V., 2019)Inhibition of carbonic anhydrase (CA) has emerged as a promising approach for the treatment of a variety of diseases such as glaucoma, epilepsy, obesity and cancer. As a result, the design of CA inhibitors (CAIs) is an ... -
İndol halkası taşıyan yeni tiyazol türevlerinin sentezi ve küçük hücreli olmayan akciğer kanseri hücreleri üzerine hedefe yönelik antikanser etkilerinin değerlendirilmesi
Baş, Seda (Anadolu Üniversitesi - Sağlık Bilimleri Enstitüsü, 2022)Bu çalışmada, on iki adet yeni tiyazolil hidrazon türevi (1-12) sentezlenmiş ve bu bileşiklerin yapıları spektroskopik yöntemler ile teyit edilmiştir. Tüm bileşiklerin A549 insan akciğer adenokarsinom hücreleri üzerine ... -
New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek (Bentham Science Publ LTD, 2019)Background: Azoles are commonly used in the treatment and prevention of fungal infections. They suppress fungal growth by acting on the heme group of lanosterol 14 alpha-demethylase enzyme (CYP51), thus blocking the ... -
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve (MDPI AG, 2017)In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with ... -
Potential inhibitors of human carbonic anhydrase isozymes I and II: Design, synthesis and docking studies of new 1,3,4-thiadiazole derivatives
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Küçükoğlu, Kaan; Onem, Hicran; Nadaroğlu, Hayrunnisa; Kaplancıklı, Zafer Asım (Pergamon-Elsevier Science LTD, 2017)In the last years, inhibition of carbonic anhydrase (CA) has emerged as a promising approach for pharmacologic intervention in a variety of disorders such as glaucoma, epilepsy, obesity, and cancer. As a consequence, the ... -
A Series of Furan-based Hydrazones: Design, Synthesis, and Evaluation of Antimicrobial Activity, Cytotoxicity and Genotoxicity
Altintop, Mehlika Dilek; Sever, Belgin; Eklioglu, Ozlem Atli; Baysal, Merve; Demirel, Rasime; Ozdemir, Ahmet (Bentham Science Publ Ltd, 2020)Background: Hydrazones, frequently occurring motifs in many bioactive molecules, have attracted a great deal of interest as potent antimicrobial agents. Objective: the aim of this work was to design and synthesize new ...
