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New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors
Karaman, Nurcan; Sıcak, Yusuf; Taşkın-Tok, Tuğba; Öztürk, Mehmet; Karakuçuk-İyidoğan, Ayşegül; Dikmen, Miriş; Oruç-Emre, Emine Elçin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Hydrazones and the piperidine ring containing compounds were considered as beneficial substrates in drug design. Therefore, this study was aimed at the synthesis of new benzoyl hydrazones derived from ethyl 4-oxopiperidi ... -
Studies on hydrazide-hydrazones derivatives as acetylcholinesterase inhibitors
Abu Mohsen, Usama; Koçyiğit-Kaymakçıoğlu, Bedia; Oruç-Emre, Emine Elçin; Kaplancıklı, Zafer Asım; Rollas, Sevim (Aves Press LTD, 2015)Objective: Fifteen hidrazide-hydrazone derivatives were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) using a modification of Ellman's spectrophotometric method. Methods: Anti-acetylc ... -
Synthesis and Anticancer Activity of New Hydrazide-hydrazoncs and Their Pd(II) Complexes
Koçyiğit-Kaymakçıoğlu, Bedia; Yazıcı, Senem Sinem; Tok, Fatih; Dikmen, Miriş; EnGür, Selin; Oruç-Emre, Emine Elçin; Iyidoğan, Ayşegül (Bentham Science Publ LTD, 2019)Background: Hydrazones, one of the important classes of organic molecules, are pharmaceutical agents comprising -CO-NH-N=CH- group in the structure therefore and exhibiting significant biological activity. Methods: ... -
Synthesis and biological activity of hydrazide-hydrazones and their corresponding 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles
Koçyiğit-Kaymakçıoğlu, Bedia; Oruç-Emre, Emine Elçin; Ünsalan, Seda; Tabanca, Nurhayat; Khan, Shabana I.; Wedge, David Earl; Rollas, Sevim (Springer Birkhauser, 2012)Various 3-acetyl-2,5-disubstituted-2,3-dihydro-1,3,4-oxadiazoles (11-20) were prepared by the reaction of aryl substituted hydrazones of 4-fluorobenzoic acid hydrazide (1-10) with acetic anhydride. The structures of the ...