Yazar "Kuş, Gökhan" için listeleme
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Açık ve uzaktan esnek öğrenme ortamlarında yapay zeka tekniğiyle strateji karar modelinin oluşturulması
Güler, Emel (Anadolu Üniversitesi - Sosyal Bilimler Enstitüsü, 2020)Bu çalışmanın temel amacı, Açık ve Uzaktan Esnek Öğrenme (AUEÖ) ortamlarının tasarımında, yapay zeka tekniğiyle odak strateji karar modelinin oluşturulmasıdır. Çalışmadaki modelin oluşturulması için esnek öğrenme yaklaşımı ... -
Açıköğretim öğrencilerinin kitap alma durumları ve başarıları arasındaki ilişkinin incelenmesi
Anadolu Üniversitesi, Açıköğretim Fakültesi; 0000-0001-5069-0132; 0000-0003-2639-4987; 0000-0002-2424-2720; Akyıldız, Murat; Usta, İlker; Okur, Muhammet Recep; Kuş, Gökhan (Anadolu Üniversitesi, 2016)Son yıllarda artan eğitim materyallerinin online ortama aktarılması eğilimine rağmen Açıköğretim sisteminde hala temel eğitim materyali basılı kitaptır. Bilgi ve iletişim teknolojilerinin çok sık kullanılmadığı dönemlerde ... -
Antiproliferative and antiapoptotic effect of thymoquinone on cancer cells in vitro
Kuş, Gökhan; Özkurt, Mete; Kabadere, Selda; Erkasap, Nilüfer; Göğer, Gamze; Demirci, Fatih (Comenius University, 2018)OBJECTIVES: Nigella sativa oil and thymoquinone were comparatively tested in vitro for their effects on human cancer cell lines (glioma, T98; prostate, LnCaP) as well as mouse embryonic fi broblast cell lines (3T3), and ... -
Ceranib-2 induces apoptosis in prostate cancer cells
Kuş, Gökhan; Kabadere, Selda; Kutlu, Hatice Mehtap; Uyar, Ruhi (Wiley-Blackwell, 2015)… -
Ceranib-2 inhibits the proliferation and induces apoptosis of glioma cells in vitro
Kabadere, Selda; Kuş, Gökhan; Öztopçu-Vatan, Pınar; Uyar, Ruhi (Wiley-Blackwell, 2015)… -
Comparative Study on Induction of Apoptosis in A549 Human Lung Adenocarcinoma Cells by C2 Ceramide or Ceranib-2
Kuş, Gökhan; Kutlu, Hatice Mehtap; Vejselova, Djanan; Çömlekçi, Emre (Zoological Soc Pakistan, 2017)Investigation of ceramide and ceramidases on cancer therapy had become popular in recent years. Ceramide is a metabolite in sphingolipid pathway of the cells that has an ability to promote cell death in tumor cells when ... -
Comparing the Role of Silymarin on Survival Rate of Rat Glioma With Primary Mixed Rat Glia Cells in Vitro
Gezgin, Duygu; Kabadere, Selda; Uyar, Ruhi; Kuş, Gökhan (Parlar Scientific Publications (PSP), 2013)Phytochemicals, nutraceuticals and herbal products, such as silymarin, have gained ever growing popularity and are valued for their ability to defend against almost all types of disease. Primarily known as hepatoprotective ... -
Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells
Kuş, Gökhan; Özkurt, Mete; Öztopçu Vatan, Pınar; Erkasap, Nilüfer; Uyar, Ruhi; Kabadere, Selda (Tubitak Scientific & Technical Research Council Turkey, 2018)Inhibiting ceramidase activity in cancer cells has been identified as a promising target for cancer therapy in recent studies. Thus, we examined the possible role of ceranib-2, a novel ceramidase inhibitor, on growth and ... -
Critical Role of Astrocytes on Striatal Neuro-Chemistry in Vip Treated Parkinsonian Rats
Tuncel, N.; Yelkenli, I; Ulupınar, E.; Korkmaz, O. T.; Şener, E.; Kuş, Gökhan (Humana Press Inc, 2013)… -
Cytotoxic and apoptotic effects of ceranib-2 offering potential for a new antineoplastic agent in the treatment of cancer cells
Vejselova, Djanan; Kutlu, Hatice Mehtap; Kuş, Gökhan; Kabadere, Selda; Uyar, Ruhi (Tubitak Scientific & Technical Research Council Turkey, 2014)Fibrocarcinomas are malignant tumours that originate in mesenchymal cells. The tumours typically form in the presence of connective tissue and are of key consideration when assessing research priorities for future healthcare ... -
Cytotoxic and Apoptotic Functions of Licofelone on Rat Glioma Cells
Kuş, Gökhan; Öztopçu-Vatan, Pınar; Uyar, Ruhi; Kabadere, Selda (Akademiai Kiado Zrt, 2013)Gliomas are the largest group of central nervous system tumors and despite of clinical treatments death rate is very high. Inhibition of both cyclooxygenase and lipoxygenase pathways that take role in arachidonic acid ... -
The effects of ceranib-2 on cancer and non-cancer cell morphology
Kutlu, Hatice Mehtap; Vejselova, Djanan; Kuş, Gökhan; Cengiz, Mustafa; Kabadere, Selda (Wiley-Blackwell, 2014)… -
The effects of ceranib-2 on cancer and non-cancer cell ultrastructure
Vejselova, Djanan; Kuş, Gökhan; Kutlu, Hatice Mehtap; Cengiz, Mustafa; Kabadere, Selda (Wiley-Blackwell, 2014)… -
Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line
Başpınar, Mustafa Serhat; Özyurt, Rumeysa; Kuş, Gökhan; Kutlay, Özden; Özkurt, Mete; Erkasap, Nilüfer; Kabadere, Selda (Comenius University, 2017)OBJECTIVE: The aim of this study was to investigate the effects of a novel anti-cancer drug, ceranib-2, which targets the acid ceramidase, in human colon cancer cell line. MATERIALS AND METHODS: The cell lines were treated ... -
Erythropoietin Protects the Kidney by Regulating the Effect of TNF-alpha in L-NAME-Induced Hypertensive Rats
Özkurt, Mete; Uzuner, Kubilay; Erkasap, Nilüfer; Kuş, Gökhan; Özyurt, Rumeysa; Uysal, Onur; Kutlay, Özden (Karger, 2018)Background/Aims: Hypertension is the leading cause of death worldwide. Chronic high blood pressure induces inflammation. Tumor necrosis factor (TNF)-alpha plays a major role in inflammation and also depresses the synthesis ... -
Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells
Vejselova, Djanan; Kutlu, Hatice Mehtap; Kuş, Gökhan (Springer, 2016)Acid ceramidases are enzymes with a vital role in metabolizing ceramide to sphingosine-1-phosphate that is an antiproliferative metabolite in the ceramide pathway. Inhibition of exogenous ceramides with ceramidase inhibitors ... -
Hepatosellüler Karsinom Hücrelerinde Karmofurun Sitotoksik ve Apoptotik Etkileri
Kuş, Gökhan (2017)Bedende istenmeyen ve potansiyel olarak tehkike arze-den hücrelerin ölümünü sağlayan apoptotik hücre ölü-mü genetik olarak kontrol edilir ve bu yolla bedendeki hücrelerin sayısı kontrol altında tutulur. Apoptoz ölüm ...
