Yazar "Evren, Asaf Evrim" için listeleme
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Bazı yeni kinolin türevlerinin sentezi, antimikrobiyal ve DNA giraz inhibitörü etkilerinin araştırılmas
Yurttaş, Leyla; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü; Evren, Asaf Evrim (Tez (yüksek lisans) - Anadolu Üniversitesi, 2019)Enfeksiyon, bir organizmada patojen mikroorganizmaların neden olduğu birtakım istenmeyen etkilerin görülmesine denir. Özellikle de bakteri ve mantar kaynaklı enfeksiyonlar sıklıkla görülmektedir. Bu rahatsızlıkların ... -
Focusing on the moderately active compound (MAC) in the design and development of strategies to optimize the apoptotic effect by molecular mechanics techniques
Evren, Asaf Evrim; Nuha, Demokrat; Yuttaş, Leyla (Anadolu Üniversitesi, 2022)Today, chemotherapeutic agents are mostly used to fight cancer in clinics. But even though they have selectivity for cancer cells, their mechanism of action could result in necrosis. Therefore, we aimed to suggest new ... -
Novel Tri-substituted Thiazoles Bearing Piperazine Ring: Synthesis and Evaluation of their Anticancer Activity
Evren, Asaf Evrim; Yurttaş, Leyla; Ekselli, Büşra; Akalın Çiftçi, Gülsen (Bentham Science Publ LTD, 2019)Background: Cancer cells are described as an unregulated growth and spread of abnormal cells. Recently, cancer has become the most important major reason for deaths in the world. Methods: For anticancer activity, we have ... -
Synthesis and Antimicrobial Activity of Some New N-(1H-benzimidazol-2yl)-2-mercaptoacetamide Derivatives
Evren, Asaf Evrim; Tekinkoca, Sinem; Yurttaş, Leyla (Bentham Science Publ LTD, 2018)Background: Due to multi-drug, extended-drug, and pandrug resistance phenotypes, bacterial resistance to antibiotics and fungal infections are a general health issue. Particulary, increase of fungal infections due to ... -
Synthesis and biological evaluation of 5-methyl-4-phenyl thiazole derivatives as anticancer agents
Evren, Asaf Evrim; Yurttaş, Leyla; Ekselli, Büsra; Akalın Çiftçi, Gülsen (Taylor & Francis LTD, 2019)New N-(5-methyl-4-phenylthiazol-2-yl)-2-(substituted thio)acetamides were synthesized and studied for their anticancer activity. The title compounds were procured by reacting 2-chloro-N-(5-methyl-4-phenylthiazol-2-yl)acetamide ... -
Synthesis and in silico evaluation of some new 2,4-disubstituted thiazole derivatives
Anadolu Üniversitesi, Eczacılık Fakültesi; Yurttaş, Leyla; Evren, Asaf Evrim; Özkay, Yusuf (Anadolu Üniversitesi, 2022)The synthesis and anti-proliferative activity investigation of methyl 3/4-[[4-(2-substituted thiazol-4-yl)phenyl]amino]-3-oxopropanoate/(4-oxobutanoate) (3a-h) derivatives were aimed in this work. The synthesis of the new ... -
Synthesis of novel N-(naphthalen-1-yl)propanamide derivatives and evaluation their antimicrobial activity
Evren, Asaf Evrim; Yurttaş, Leyla; Yılmaz-Cankılıç, M. (Taylor and Francis Ltd., 2019)New N-(naphthalen-1-yl)propanamide was synthesized and studied for their antimicrobial activity. The final compounds were procured by reacting N-(naphthalen-1-yl)propanamide with some 2-mercapto aryl or dithiocarbamate ... -
Synthesis of some novel 3,4,5-trisubstituted triazole derivatives bearing quinoline ring and evaluation of their antimicrobial activity
Yurttas, Leyla; Kubilay, Aslihan; Evren, Asaf Evrim; Kisacik, Ipek; Karaca Gencer, Hulya (Taylor & Francis Ltd, 9999)Some new 3,4,5-trisubstituted 1,2,4-triazole derivatives were synthesized and studied for their antimicrobial activity. the lead compounds were obtained starting from 8-hydroxyquinoline and ethyl 2-chloroacetate. the ...
