Yazar "Öztopçu-Vatan, Pınar" için listeleme
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Ceranib-2 inhibits the proliferation and induces apoptosis of glioma cells in vitro
Kabadere, Selda; Kuş, Gökhan; Öztopçu-Vatan, Pınar; Uyar, Ruhi (Wiley-Blackwell, 2015)… -
Cytotoxic and Apoptotic Functions of Licofelone on Rat Glioma Cells
Kuş, Gökhan; Öztopçu-Vatan, Pınar; Uyar, Ruhi; Kabadere, Selda (Akademiai Kiado Zrt, 2013)Gliomas are the largest group of central nervous system tumors and despite of clinical treatments death rate is very high. Inhibition of both cyclooxygenase and lipoxygenase pathways that take role in arachidonic acid ... -
The investigation of ceranib-2 on apoptosis and drug interaction with carboplatin in human non small cell lung cancer cells in vitro
Yıldız-Özer, Merve; Öztopçu-Vatan, Pınar; Kuş, Gökhan (Springer, 2018)Ceramide is found to be involved in inhibition of cell division and induction of apoptosis in certain tumour cells. Ceranib-2 is an agent that increases ceramide levels by inhibiting ceramidase in cancer cells. Therefore, ... -
Licofelone abolishes survival of carcinogenic fibroblasts by inducing apoptosis
Kabadere, Selda; Kuş, Gökhan; Uyar, Ruhi; Öztopçu-Vatan, Pınar (Informa Healthcare, 2014)Dual inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX) pathways of arachidonic acid metabolism prevent cancer development and induce apoptosis. One of the most promising compounds that blocks both of these pathways ... -
Licofelone Inhibits Proliferation of Rat Hepatoma Cells
Öztopçu-Vatan, Pınar; Kuş, Gökhan; Man, Emine; Korkut, Melek Gunindi; Kabadere, Seida; Uyar, Ruhi (Zoological Soc Pakistan, 2017)Despite clinical treatments, hepatocellular carcinoma is one of the most common causes of cancer death. We tested whether licofelone, an inhibitor of both cyclooxygenase and lipoxygenase pathways of arachidonic acid ... -
Screening of Antimicrobial, Cytotoxic Effects and Phenolic Compounds of the Moss Aulacomnium Androgynum (Hedw.) Schwagr (Bryophyta)
Öztopçu-Vatan, Pınar; Savaroğlu, F.; İşcen, C. F.; Kabadere, Selda; Öztürk, Nilgün; İlhan, S. (Pakistan Agricultural Scientists Forum, 2017)The second largest taxonomic group in the kingdom plantae is bryophytes, however; studies carried out to better understand their chemical composition are limited and dispersed. In this study, phenolic compounds, the ... -
Synthesis and evaluation of naphthalene-based thiosemicarbazone derivatives as new anticancer agents against LNCaP prostate cancer cells
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Kuş, Gökhan; Öztopçu-Vatan, Pınar; Kabadere, Selda; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)Fourteen new naphthalene-based thiosemicarbazone derivatives were designed as anticancer agents against LNCaP human prostate cancer cells and synthesized. MTT assay indicated that compounds 6, 8 and 11 exhibited inhibitory ...
