Yazar "Özkurt, Mete" için listeleme
-
Antiproliferative and antiapoptotic effect of thymoquinone on cancer cells in vitro
Kuş, Gökhan; Özkurt, Mete; Kabadere, Selda; Erkasap, Nilüfer; Göğer, Gamze; Demirci, Fatih (Comenius University, 2018)OBJECTIVES: Nigella sativa oil and thymoquinone were comparatively tested in vitro for their effects on human cancer cell lines (glioma, T98; prostate, LnCaP) as well as mouse embryonic fi broblast cell lines (3T3), and ... -
Comparison of a ceramidase inhibitor (ceranib-2) with C2 ceramide and cisplatin on cytotoxicity and apoptosis of glioma cells
Kuş, Gökhan; Özkurt, Mete; Öztopçu Vatan, Pınar; Erkasap, Nilüfer; Uyar, Ruhi; Kabadere, Selda (Tubitak Scientific & Technical Research Council Turkey, 2018)Inhibiting ceramidase activity in cancer cells has been identified as a promising target for cancer therapy in recent studies. Thus, we examined the possible role of ceranib-2, a novel ceramidase inhibitor, on growth and ... -
Effects of ceranib-2 on cell survival and TNF-alpha in colon cancer cell line
Başpınar, Mustafa Serhat; Özyurt, Rumeysa; Kuş, Gökhan; Kutlay, Özden; Özkurt, Mete; Erkasap, Nilüfer; Kabadere, Selda (Comenius University, 2017)OBJECTIVE: The aim of this study was to investigate the effects of a novel anti-cancer drug, ceranib-2, which targets the acid ceramidase, in human colon cancer cell line. MATERIALS AND METHODS: The cell lines were treated ... -
Erythropoietin Protects the Kidney by Regulating the Effect of TNF-alpha in L-NAME-Induced Hypertensive Rats
Özkurt, Mete; Uzuner, Kubilay; Erkasap, Nilüfer; Kuş, Gökhan; Özyurt, Rumeysa; Uysal, Onur; Kutlay, Özden (Karger, 2018)Background/Aims: Hypertension is the leading cause of death worldwide. Chronic high blood pressure induces inflammation. Tumor necrosis factor (TNF)-alpha plays a major role in inflammation and also depresses the synthesis ... -
Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies
Sever, Belgin; Altıntop, Mehlika Dilek; Kuş, Gökhan; Özkurt, Mete; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)In the current work, new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives (1-8) were synthesized via the ring closure reaction of 2-bromoacetophenone derivatives with 4-amino-5-[(5-methoxy-2-methyl-1(4-chlorobenzoyl)- ... -
Possible Antiproliferative Effect of Tolfenamic Acid on Human LNCaP Prostate Cancer Cell Lines
Ertekin, Rıfat; Özkurt, Mete; Kuş, Gökhan; Kabadere, Selda (Zoological Soc Pakistan, 2019)Prostate cancer is a common type of cancer. Contemporary treatment modalities require that new, effective methods or chemicals should be developed. Tolfenamic acid (TA) is a nonsteroidal anti-inflammatory medicine stimulating ...
