Yazar "Can, Nafiz Öncü" için listeleme
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A new HPLC method for selexipag analysis in pharmaceutical formulation and bulk form
Anadolu Üniversitesi; 0000-0002-5492-0457; 0009-0007-6708-1166; 0000-0003-3692-163X; 0000-0003-0280-518X; Özcan, Saniye; Öğüt, Egemen Güvenç; Levent, Serkan; Can, Nafiz Öncü (Anadolu Üniversitesi, 2023)Selexipag is a new non-prostanoid prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Selexipag is a long-acting IP receptor agonist with a shorter half-life than all other licensed drugs targeting ... -
A novel dilute and shoot HPLC assay method for quantification of irbesartan and hydrochlorothiazide in combination tablets and urine using second generation C-18-bonded monolithic silica column with double gradient elution
Koyutürk, Sema; Can, Nafiz Öncü; Atkoşar, Zeki; Arli, Göksel (Elsevier Science BV, 2014)Irbesartan (IRB) and hydrochlorothiazide (HCT) are angiotensin-ll receptor antagonist and thiazide-class diuretic compounds, respectively, which are in use in the treatment of hypertension. A novel diluteand-shoot HPLC ... -
A novel RP-HPLC method for simultaneous determination of potassium sorbate and sodium benzoate in soft drinks using C-18-bonded monolithic silica column
Can, Nafiz Öncü; Arli, Göksel; Lafçı, Yiğit (Wiley Periodicals, Inc, 2011)Potassium sorbate and sodium benzoate are food additives that are generally employed for prevention of food spoilage originating from bacteria, molds or yeasts. Although these compounds were generally recognized as safe ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Rapid determination of free anthocyanins in foodstuffs using high performance liquid chromatography
Can, Nafiz Öncü; Arli, Göksel; Atkoşar, Zeki (Elsevier Sci LTD, 2012)Anthocyanins constitute a major group of natural pigments, and they are responsible for the colours of fruits and vegetables. A rapid and feasible assay procedure for the determination of free forms of the six most abundant ... -
Reversed-phase HPLC analysis of levetiracetam in tablets using monolithic and conventional c18 silica column
Can, Nafiz Öncü; Arli, Göksel (2010)Development and validation of an RP-HPLC method for determination of levetiracetam in pharmaceutical tablets is described. The separation and quantification of levetiracetam and caffeine (internal standard) were performed ... -
Reversed-Phase HPLC Analysis of Levetiracetam in Tablets Using Monolithic and Conventional C18 Silica Columns
Can, Nafiz Öncü; Arli, Göksel (Aoac Int, 2010)Development and validation of an RP-HPLC method for determination of levetiracetam in pharmaceutical tablets is described. The separation and quantification of levetiracetam and caffeine (internal standard) were performed ... -
Sefuroksim aksetil'in UV-spektrofotometri, akış enjeksiyon analizi ve yüksek basınçlı sıvı kromatografisi yöntemleri ile tabletlerdeki miktarının tayini
Can, Nafiz Öncü (Anadolu Üniversitesi, 2002)Bu çalışmada, Sefuroksim aksetil'in tablet formülasyonlarındaki miktarının tayini için UV-spektrofotometri, akış enjeksiyon (AE) ve fotodiyot dizisi dedektörlü yüksek basınçlı sıvı kromatografisi (YBSK) tekniklerinin ... -
Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
Can, Nafiz Öncü; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; İnci, Beril; Ilgın, Sinem; Kaplancıklı, Zafer Asım (MDPI, 2017)In the present work, 14 new 1-substituted-2-phenylhydrazone derivatives were synthesized to evaluate their inhibitory activity against hMAO enzymes. The structures of the newly synthesized hydrazones 2a-2n were characterized ... -
Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities
Can, Nafiz Öncü; Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir (MDPI, 2018)Novel thiadiazole derivatives were synthesized through the reaction of acetylated 2-aminothiadiazole and piperazine derivatives. The chemical structures of the compounds were clarified by Infrared Spectroscopy (IR), H-1 ... -
Synthesis, Molecular Docking Studies, and Antifungal Activity Evaluation of New Benzimidazole-Triazoles as Potential Lanosterol 14 alpha-Demethylase Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Levent, Serkan; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Koparal, Ali Savaş (Hindawi LTD, 2017)Due to anticandidal importance of azole compounds, a new series of benzimidazole-triazole derivatives(5a-5s) were designed and synthesized as ergosterol inhibitors. Thechemical structures of the target compounds were ... -
Trifluridin ve tipiracil hidroklorürün farmasötik preparatlardan eş zamanlı tayini için UPLC ve LC-MS/MS yöntemlerinin geliştirilmesi ve bozunma ürünlerinin LCMS-IT-TOF ile karakterizasyonu
Kozanlı, Murat (Anadolu Üniversitesi - Sağlık Bilimleri Enstitüsü, 2022)Kanser, tüm dünyada kardiyovasküler hastalıklardan sonra en çok ölümle sonuçlanan hastalıktır. Ve insanlarda görülme sıklığı her geçen gün artmaktadır. Kolon kanseri, kanser insidansı ve mortalite sıralamasında çok yüksek ... -
Validated reversed phase HPLC method for the analysis of the food additive, sodium benzoate, in soft drinks and jams
Altıokka, Göksel; Ergün, Bülent; Can, Nafiz Öncü; Aboul-Enein, Hassan Y. (Taylor & Francis Inc, 2007)A rapid, simple, and sensitive method is described for the determination of the food preservative sodium benzoate in soft drinks, various jams, and ketchup. The method utilizes high performance liquid chromatography followed ...