Yazar "Çevik, Ulviye Acar" için listeleme
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Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Ardıç, Cankiz Mina; Özkay, Yusuf; Atlı Eklioğlu, Özlem (Walter De Gruyter GMBH, 2018)Objectives: Cancer is one of the leading causes of death throughout the world. Current therapy options suffer from the major limitations of side effects and drug resistance. Thus, continuing search for newer and safer ... -
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Cantürk, Zerrin; Bueno, Juan; Demirci, Fatih; Koparal, Ali Savaş (Bentham Science Publ LTD, 2017)In the present study, nineteen new fluoro-benzimidazole derivatives, including nifuroxazide analogs, were synthesized by microwave-supported reactions and tested against a panel of pathogenic microorganisms consisting of ... -
Synthesis of Novel 4-(Dimethylaminoalkyl) piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors
Çevik, Ulviye Acar; Levent, Serkan; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2017)Background: Carbamate compounds have attracted a great deal of interest in medicinal chemistry due to their inhibition potential against cholinesterase enzymes. Method: Hence, this study was undertaken to synthesize new ... -
Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
Levent, Serkan; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI AG, 2017)In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel ... -
Synthesis, Characterization, and Molecular Docking Study of Some Novel Imidazole Derivatives as Potential Antifungal Agents
Işık, Ayşen; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf (Wiley, 2019)The azole pharmacophore is still regarded as a viable lead structure for the synthesis of more effective antifungal agents. In this study, two novel series of imidazole derivatives containing dithiocarbamate (5a-5g) and ... -
Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives
Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Kaya Çavuşoğlu, Betül; Demir, Y. (NLM (Medline), 2019)New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II ... -
Synthesis, Molecular Docking Studies, and Antifungal Activity Evaluation of New Benzimidazole-Triazoles as Potential Lanosterol 14 alpha-Demethylase Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Levent, Serkan; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Koparal, Ali Savaş (Hindawi LTD, 2017)Due to anticandidal importance of azole compounds, a new series of benzimidazole-triazole derivatives(5a-5s) were designed and synthesized as ergosterol inhibitors. Thechemical structures of the target compounds were ...